Rabbit Anti-FBXW5 Polyclonal Antibody – Cat# MBS6004882

FBXW5 Antibody (Center) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the FBXW5 antibody detected the FBXW5 protein (arrow).

FBXW5 Antibody – Rabbit Polyclonal

Name: FBXW5 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6004882
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6004882

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FBXW5, Polyclonal Antibody

Full Product Name

FBXW5, ID (FBXW5, FBW5, F-box/WD repeat-containing protein 5, F-box and WD-40 domain-containing protein 5)

Product Gene Name

anti-FBXW5 antibody

Product Synonym Names

Anti -FBXW5, ID (FBXW5, FBW5, F-box/WD repeat-containing protein 5, F-box and WD-40 domain-containing protein 5)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Human

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

63,922 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (139834885..139839298, complement). Location: 9q34.3

OMIM

609072

3D Structure

ModBase 3D Structure for Q969U6

Immunogen

FBXW5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 324-350 amino acids from the Central region of human FBXW5.

Product Categories/Family for anti-FBXW5 antibody

Antibodies; Abs to WD Repeat Proteins

Applications Tested/Suitable for anti-FBXW5 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-FBXW5 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-FBXW5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FBXW5 purchase

MBS6004882 is an antibody targeting FBXW5. Also known as FBXW5, ID (FBXW5, FBW5, F-box/WD repeat-containing protein 5, F-box and WD-40 domain-containing protein 5). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FBXW5. It may not necessarily be applicable to this product.

NCBI GI #

24308129

NCBI GeneID

54461

NCBI Accession #

NP_061871.1

UniProt Primary Accession #

Q969U6

UniProt Secondary Accession #

Q59ET5; Q5SPZ8; Q5SPZ9; Q5SQ00; Q5SQ02; Q5SQ03; Q5SQ04; Q8WY79; Q96GJ6; Q9BSU8; B2RDZ6

UniProt Related Accession #

Q969U6

GenBank Nucleotide #

NM_018998.3

NCBI Official Full Name

F-box/WD repeat-containing protein 5

NCBI Official Synonym Full Names

F-box and WD repeat domain containing 5

NCBI Official Symbol

FBXW5

NCBI Official Synonym Symbols

Fbw5

UniProt Protein Name

F-box/WD repeat-containing protein 5

UniProt Synonym Protein Names

F-box and WD-40 domain-containing protein 5

Protein Family

F-box/WD repeat-containing protein

UniProt Gene Name

FBXW5

UniProt Synonym Gene Names

FBW5

UniProt Entry Name

FBXW5_HUMAN

NCBI Protein Information

F-box/WD repeat-containing protein 5; WD repeat-containing F-box protein FBW5; F-box and WD-40 domain-containing protein 5

UniProt Comments for FBXW5

FBXW5: Substrate recognition component of both SCF (SKP1-CUL1- F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. Belongs to the FBXW5 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytoplasm; SCF ubiquitin ligase complex

Molecular Function: protein binding; protein kinase binding

Biological Process: mitosis; proteasomal ubiquitin-dependent protein catabolic process; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; centrosome duplication

Research Articles on FBXW5

1. Identify Fbxw5-driven fluctuation of Eps8 levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-FBXW5 antibody

Products by Pathway	Pathway Diagram
Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway antibodies	Association Of TriC/CCT With Target Proteins During Biosynthesis Pathway Diagram
Chaperonin-mediated Protein Folding Pathway antibodies	Chaperonin-mediated Protein Folding Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Protein Folding Pathway antibodies	Protein Folding Pathway Diagram

Organs/Tissues associated with anti-FBXW5 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with FBXW5 and Lung