Receptor (EPHA4) Antibody – Mouse Monoclonal

EphA4: a tyrosine kinase receptor of the Eph family. Receptor for members of the ephrin-A family. Binds to ephrin-A1, -A4 and -A5. Binds more poorly to ephrin-A2 and -A3. May play a role in hindbrain pattern formation. The Eph receptor tyrosine kinase family, the largest in the tyrosine kinase group, has fourteen members. They bind membrane-anchored ligands, ephrins, at sites of cell-cell contact, regulating the repulsion and adhesion of cells that underlie the establishment, maintenance, and remodeling of patterns of cellular organization. Eph signals are particularly important in regulating cell adhesion and cell migration during development, axon guidance, homeostasis and disease. EphA receptors bind to GPI-anchored ephrin-A ligands, while EphB receptors bind to ephrin-B proteins that have a transmembrane and cytoplasmic domain. Interactions between EphB receptor kinases and ephrin-B proteins transduce signals bidirectionally, signaling to both interacting cell types. Eph receptors and ephrins also regulate the adhesion of endothelial cells and are required for the remodeling of blood vessels.

Protein type: Protein kinase, TK; Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Eph family

Cellular Component: Golgi apparatus; cell surface; endoplasmic reticulum; integral to plasma membrane; postsynaptic density; dendrite; dendritic spine; integral to membrane; perikaryon; postsynaptic membrane; mitochondrial outer membrane; cell projection; membrane; early endosome membrane; axon; cytoplasm; plasma membrane; synapse; nerve terminal; neuromuscular junction; cell junction; endosome; filopodium

Molecular Function: identical protein binding; transmembrane-ephrin receptor activity; ephrin receptor binding; nucleotide binding; transmembrane receptor protein tyrosine kinase activity; protein kinase activity; transferase activity; protein binding; protein-tyrosine kinase activity; GPI-linked ephrin receptor activity; transferase activity, transferring phosphorus-containing groups; ephrin receptor activity; kinase activity; PH domain binding; ATP binding

Biological Process: positive regulation of JNK activity; nervous system development; axon guidance; regulation of GTPase activity; peptidyl-tyrosine phosphorylation; negative regulation of axon regeneration; multicellular organismal development; protein amino acid autophosphorylation; motor axon guidance; regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; glial cell migration; regulation of axonogenesis; adult walking behavior; protein amino acid phosphorylation; ephrin receptor signaling pathway; corticospinal tract morphogenesis; cell adhesion; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway