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PCCA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005102

The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PCCA, Polyclonal Antibody
Full Product Name
PCCA, ID (PCCA, Propionyl-CoA carboxylase alpha chain, mitochondrial, Propanoyl-CoA:carbon dioxide ligase subunit alpha)
Product Gene Name
anti-PCCA antibody
Product Synonym Names
Anti -PCCA, ID (PCCA, Propionyl-CoA carboxylase alpha chain, mitochondrial, Propanoyl-CoA:carbon dioxide ligase subunit alpha)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
80,059 Da
Chromosome Location
Chromosome: 13; NC_000013.10 (100741269..101182691). Location: 13q32
OMIM
232000
3D Structure
ModBase 3D Structure for P05165
Immunogen
PCCA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-365 amino acids from the Central region of human PCCA.

Product Categories/Family for anti-PCCA antibody

Antibodies; Abs to Mitochondrial Proteins
Applications Tested/Suitable for anti-PCCA antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PCCA antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-PCCA antibody

PCCA Antibody (Center) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the PCCA antibody detected the PCCA protein (arrow).
Rabbit Anti-PCCA Polyclonal Antibody – Cat# MBS6005102

Immunohistochemistry (IHC) of anti-PCCA antibody

PCCA Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human breast tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PCCA Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PCCA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6005102

Other Notes

Small volumes of anti-PCCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PCCA purchase

MBS6005102 is an antibody targeting PCCA. Also known as PCCA, ID (PCCA, Propionyl-CoA carboxylase alpha chain, mitochondrial, Propanoyl-CoA:carbon dioxide ligase subunit alpha). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PCCA. It may not necessarily be applicable to this product.

NCBI GI #
295821183
NCBI GeneID
5095
NCBI Accession #
NP_001171475.1
UniProt Primary Accession #
P05165
UniProt Secondary Accession #
Q15979; Q8WXQ7; B4DKY8; B4DPF9; C9JPQ8
UniProt Related Accession #
P05165
GenBank Nucleotide #
NM_001178004.1
NCBI Official Full Name
propionyl-CoA carboxylase alpha chain, mitochondrial isoform c
NCBI Official Synonym Full Names
propionyl CoA carboxylase, alpha polypeptide
NCBI Official Symbol
PCCA
UniProt Protein Name
Propionyl-CoA carboxylase alpha chain, mitochondrial
UniProt Synonym Protein Names
Propanoyl-CoA:carbon dioxide ligase subunit alpha
UniProt Gene Name
PCCA
UniProt Synonym Gene Names
PCCase subunit alpha
UniProt Entry Name
PCCA_HUMAN
NCBI Protein Information
propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase alpha subunit; pccA complementation group; propanoyl-CoA:carbon dioxide ligase alpha subunit; propionyl Coenzyme A carboxylase, alpha polypeptide

UniProt Comments for PCCA

PCCA: Defects in PCCA are the cause of propionic acidemia type I (PA-1). PA-1 is a life-threatening disease characterized by episodic vomiting, lethargy and ketosis, neutropenia, periodic thrombocytopenia, hypogammaglobulinemia, developmental retardation, and intolerance to protein. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 6.4.1.3; Mitochondrial; Carbohydrate Metabolism - propanoate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Ligase

Chromosomal Location of Human Ortholog: 13q32

Cellular Component: mitochondrial matrix; cytosol

Molecular Function: enzyme binding; metal ion binding; propionyl-CoA carboxylase activity; biotin carboxylase activity; biotin binding; ATP binding

Biological Process: fatty acid beta-oxidation; vitamin metabolic process; short-chain fatty acid catabolic process; cellular lipid metabolic process; water-soluble vitamin metabolic process; biotin metabolic process

Disease: Propionic Acidemia
Show more

Research Articles on PCCA

1. Thsi study presented that Propionic acidemia(PCCA mutation) associated with visual hallucinations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PCCA antibody

 Reference Product  PubMed Publications
 PCCB antibody  >47 publications with PCCA and PCCB
 MUT antibody  >3 publications with PCCA and MUT
 ACAA2 antibody  >1 publications with PCCA and ACAA2
 MCEE antibody  >1 publications with PCCA and MCEE

Pathways associated with anti-PCCA antibody

 Products by Pathway  Pathway Diagram
 2-oxobutanoate Degradation I Pathway antibodies  2-oxobutanoate Degradation I Pathway Diagram
 Biotin Transport And Metabolism Pathway antibodies  Biotin Transport And Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Carbon Metabolism Pathway antibodies  Carbon Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Glyoxylate And Dicarboxylate Metabolism Pathway antibodies  Glyoxylate And Dicarboxylate Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Vitamins And Cofactors Pathway antibodies  Metabolism Of Vitamins And Cofactors Pathway Diagram

Diseases associated with anti-PCCA antibody

 Disease Name  Pubmed Publications
 Propionic Acidemia Antibodies  >48 publications with PCCA and Propionic Acidemia
 Disease Models, Animal Antibodies  >4 publications with PCCA and Disease Models, Animal
 Fatty Liver Antibodies  >4 publications with PCCA and Fatty Liver
 Brain Diseases Antibodies  >4 publications with PCCA and Brain Diseases
 Liver Diseases Antibodies  >4 publications with PCCA and Liver Diseases
 Neoplasms Antibodies  >3 publications with PCCA and Neoplasms
 Seizures Antibodies  >3 publications with PCCA and Seizures
 Carcinoma Antibodies  >2 publications with PCCA and Carcinoma
 Adenocarcinoma Antibodies  >2 publications with PCCA and Adenocarcinoma
 Atrophy Antibodies  >2 publications with PCCA and Atrophy

Organs/Tissues associated with anti-PCCA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >40 publications with PCCA and Blood
 Liver Antibodies  >13 publications with PCCA and Liver
 Vascular Antibodies  >6 publications with PCCA and Vascular
 Skin Antibodies  >5 publications with PCCA and Skin
 Heart Antibodies  >5 publications with PCCA and Heart
 Brain Antibodies  >3 publications with PCCA and Brain
 Muscle Antibodies  >2 publications with PCCA and Muscle
 Nerve Antibodies  >2 publications with PCCA and Nerve
 Embryonic Tissue Antibodies  >2 publications with PCCA and Embryonic Tissue
 Placenta Antibodies  >2 publications with PCCA and Placenta
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