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MYO3B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005105

MBS6005105 is an antibody targeting MYO3B. Also known as MYO3B, CT (MYO3B, Myosin-IIIb). Reactive in Human. Host: Rabbit. MYO3B is probable actin-based motor with a protein kinase activity. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MYO3B, Polyclonal Antibody
Full Product Name
MYO3B, CT (MYO3B, Myosin-IIIb)
Product Gene Name
anti-MYO3B antibody
Product Synonym Names
Anti -MYO3B, CT (MYO3B, Myosin-IIIb)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
151,829 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (171034655..171511674). Location: 2q31.1-q31.2
OMIM
610040
3D Structure
ModBase 3D Structure for Q8WXR4
Immunogen
MYO3B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MYO3B.

Product Categories/Family for anti-MYO3B antibody

Antibodies; Abs to Myosin
Applications Tested/Suitable for anti-MYO3B antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MYO3B antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-MYO3B antibody

MYO3B Antibody (C-term) western blot analysis in uterus tumor cell line lysates (35ug/lane).This demonstrates the MYO3B antibody detected the MYO3B protein (arrow).
Rabbit Anti-MYO3B Polyclonal Antibody – Cat# MBS6005105

Immunohistochemistry (IHC) of anti-MYO3B antibody

MYO3B Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of MYO3B Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-MYO3B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6005105

Other Notes

Small volumes of anti-MYO3B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MYO3B. It may not necessarily be applicable to this product.

NCBI GI #
284172512
NCBI GeneID
140469
NCBI Accession #
NP_620482.3
UniProt Primary Accession #
Q8WXR4
UniProt Secondary Accession #
Q53QE1; Q53T08; Q8IX64; Q8IX65; Q8IX66; Q8IX67; Q8IX68; Q96N94; B8ZZR2
UniProt Related Accession #
Q8WXR4
GenBank Nucleotide #
NM_138995.4
NCBI Official Full Name
myosin-IIIb isoform 2
NCBI Official Synonym Full Names
myosin IIIB
NCBI Official Symbol
MYO3B
UniProt Protein Name
Myosin-IIIb
Protein Family
Myosin
UniProt Gene Name
MYO3B
UniProt Entry Name
MYO3B_HUMAN
NCBI Protein Information
myosin-IIIb

NCBI Summary for MYO3B

This gene encodes one of the class III myosins. Myosins are ATPases, activated by actin, that move along actin filaments in the cell. This class of myosins are characterized by an amino-terminal kinase domain and shown to be present in photoreceptors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]
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UniProt Comments for MYO3B

MYO3B: an actin-based motor protein with protein kinase activity. A member of the myosin superfamily. Has a kinase domain of the STE20 family N-terminal to the conserved N-terminal motor domain. Expressed in retina, kidney and testis. Six alternatively spliced human isoforms have been described.

Protein type: Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, STE; Kinase, protein; Motor; Actin-binding; STE group; STE20 family; NinaC subfamily

Chromosomal Location of Human Ortholog: 2q31.1-q31.2

Cellular Component: filopodium tip; photoreceptor outer segment; photoreceptor inner segment; cytoplasm; stereocilium bundle tip; myosin complex

Molecular Function: microfilament motor activity; protein serine/threonine kinase activity; actin binding; ATP binding

Biological Process: positive regulation of filopodium formation; peptidyl-serine phosphorylation; visual perception; protein amino acid autophosphorylation; response to stimulus; peptidyl-threonine phosphorylation
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Research Articles on MYO3B

1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-MYO3B antibody

 Disease Name  Pubmed Publications
 Prostatic Diseases Antibodies  >1 publications with MYO3B and Prostatic Diseases
 Inflammation Antibodies  >1 publications with MYO3B and Inflammation
 Neoplasms Antibodies  >1 publications with MYO3B and Neoplasms

Organs/Tissues associated with anti-MYO3B antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >2 publications with MYO3B and Testis
 Kidney Antibodies  >1 publications with MYO3B and Kidney
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