Goat Anti-CDYL Polyclonal Antibody – Cat# MBS6005113

staining (1ug/ml) of Human Testes lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

CDYL Antibody – Goat Polyclonal

Name: CDYL Antibody; Polyclonal; Goat; MyBioSource
Brand: MyBioSource
SKU: MBS6005113
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005113

Acts as repressor of transcription. Has histone acetyltransferase activity, with a preference for histone H4. More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CDYL, Polyclonal Antibody

Full Product Name

CDYL (DKFZP586C1622, chromodomain protein, Y chromosome-like, CDY-like, autosomal, testis-specific chromodomain Y-like protein)

Product Gene Name

anti-CDYL antibody

Product Synonym Names

Anti -CDYL (DKFZP586C1622, chromodomain protein, Y chromosome-like, CDY-like, autosomal, testis-specific chromodomain Y-like protein)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Bovine, Canine, Human, Mouse, Porcine, Rat

Form/Format

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human CDYL. Species sequence homology: Bovine, canine, mouse, porcine and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

66,482 Da

Chromosome Location

Chromosome: 6; NC_000006.11 (4706393..4955778). Location: 6p25.1

OMIM

603778

3D Structure

ModBase 3D Structure for Q9Y232

Immunogen

Synthetic peptide corresponding to C-SMLKYLQRKIDEF, from human CDYL, at C-terminal (NP_004815.3, NP_001137442.1, NP_001137443.1).

Product Categories/Family for anti-CDYL antibody

Antibodies; Abs to Spermatogenesis; Testis Proteins

Applications Tested/Suitable for anti-CDYL antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CDYL antibody

Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:4000
Western Blot: 1-3ug/ml

Other Notes

Small volumes of anti-CDYL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDYL purchase

MBS6005113 is an antibody targeting CDYL. Also known as CDYL (DKFZP586C1622, chromodomain protein, Y chromosome-like, CDY-like, autosomal, testis-specific chromodomain Y-like protein). Reactive in Bovine, Canine, Human, Mouse, Porcine, Rat. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for CDYL. It may not necessarily be applicable to this product.

NCBI GI #

221307494

NCBI GeneID

9425

NCBI Accession #

NP_004815.3

UniProt Primary Accession #

Q9Y232

UniProt Secondary Accession #

Q0VDG7; Q32NC5; Q5VX99; Q6P7T5; Q9BWZ2; Q9Y424; A8K6D6; B4DLG4

UniProt Related Accession #

Q9Y232

GenBank Nucleotide #

NM_004824.3

NCBI Official Full Name

chromodomain Y-like protein isoform a

NCBI Official Synonym Full Names

chromodomain protein, Y-like

NCBI Official Symbol

CDYL

NCBI Official Synonym Symbols

CDYL1

UniProt Protein Name

Chromodomain Y-like protein

Protein Family

Chromodomain Y-like protein

UniProt Gene Name

CDYL

UniProt Synonym Gene Names

CDYL1; CDY-like

UniProt Entry Name

CDYL1_HUMAN

NCBI Protein Information

chromodomain Y-like protein; CDY-like, autosomal; testis-specific chromodomain Y-like protein

NCBI Summary for CDYL

Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

UniProt Comments for CDYL

CDYL: Acts as repressor of transcription. Has histone acetyltransferase activity, with a preference for histone H4. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Acetyltransferase; Transcription, coactivator/corepressor; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 6p25.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; histone acetyltransferase activity; transcription corepressor activity; methylated histone residue binding

Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; spermatogenesis; histone acetylation

Research Articles on CDYL

1. CDYL functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDYL antibody

Reference Product	PubMed Publications
G9A antibody	>4 publications with CDYL and G9A
HDAC1 antibody	>3 publications with CDYL and HDAC1
WIZ antibody	>1 publications with CDYL and WIZ
EHMT2 antibody	>1 publications with CDYL and EHMT2
SETDB1 antibody	>1 publications with CDYL and SETDB1
HDAC2 antibody	>1 publications with CDYL and HDAC2

Diseases associated with anti-CDYL antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>3 publications with CDYL and Neoplasms
Infertility, Male Antibodies	>1 publications with CDYL and Infertility, Male

Organs/Tissues associated with anti-CDYL antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>4 publications with CDYL and Testis
Nerve Antibodies	>2 publications with CDYL and Nerve
Liver Antibodies	>2 publications with CDYL and Liver
Bone Antibodies	>1 publications with CDYL and Bone
Skin Antibodies	>1 publications with CDYL and Skin
Embryonic Tissue Antibodies	>1 publications with CDYL and Embryonic Tissue