Rabbit Anti-SEC14L2 Polyclonal Antibody – Cat# MBS6005432

SEC14L2 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SEC14L2 antibody detected the SEC14L2 protein (arrow).

SEC14L2 Antibody – Rabbit Polyclonal

Name: SEC14L2 Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6005432
Price: 895 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005432

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream… More details

$895 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SEC14L2, Polyclonal Antibody

Full Product Name

SEC14L2, NT (SEC14L2, C22orf6, KIAA1186, KIAA1658, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor)

Product Gene Name

anti-SEC14L2 antibody

Product Synonym Names

Anti -SEC14L2, NT (SEC14L2, C22orf6, KIAA1186, KIAA1658, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor)

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein A affinity chromatography.

Specificity

Mouse

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

46,145 Da

Chromosome Location

Chromosome: 22; NC_000022.10 (30792930..30821291). Location: 22q12.2

OMIM

607558

3D Structure

ModBase 3D Structure for O76054

Immunogen

SEC14L2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-69 amino acids from the N-terminal region of human SEC14L2.

Product Categories/Family for anti-SEC14L2 antibody

Antibodies; Abs to KIAA; orf

Applications Tested/Suitable for anti-SEC14L2 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-SEC14L2 antibody

Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500

Other Notes

Small volumes of anti-SEC14L2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SEC14L2 purchase

MBS6005432 is an antibody targeting SEC14L2. Also known as SEC14L2, NT (SEC14L2, C22orf6, KIAA1186, KIAA1658, SEC14-like protein 2, Alpha-tocopherol-associated protein, Squalene transfer protein, Supernatant protein factor). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SEC14L2. It may not necessarily be applicable to this product.

NCBI GI #

323639472

NCBI GeneID

23541

NCBI Accession #

NP_001191133.1

UniProt Primary Accession #

O76054

UniProt Secondary Accession #

Q53EQ2; Q6PD61; Q9ULN4; B7Z8Q1; F5H3U4

UniProt Related Accession #

O76054

GenBank Nucleotide #

NM_001204204.1

NCBI Official Full Name

SEC14-like protein 2 isoform 3

NCBI Official Synonym Full Names

SEC14-like 2 (S. cerevisiae)

NCBI Official Symbol

SEC14L2

NCBI Official Synonym Symbols

SPF; TAP; TAP1; C22orf6

UniProt Protein Name

SEC14-like protein 2

UniProt Synonym Protein Names

Alpha-tocopherol-associated protein; TAP; hTAP; Squalene transfer protein; Supernatant protein factor

Protein Family

SEC14-like protein

UniProt Gene Name

SEC14L2

UniProt Synonym Gene Names

C22orf6; KIAA1186; KIAA1658; TAP; hTAP; SPF

UniProt Entry Name

S14L2_HUMAN

NCBI Protein Information

SEC14-like protein 2; squalene transfer protein; supernatant protein factor; tocopherol-associated protein; alpha-tocopherol-associated protein

UniProt Comments for SEC14L2

SEC14L2: Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid-binding

Chromosomal Location of Human Ortholog: 22q12.2

Cellular Component: cytoplasm; integral to membrane; nucleus

Molecular Function: transporter activity; phospholipid binding; vitamin E binding

Biological Process: transcription, DNA-dependent; transport; regulation of cholesterol biosynthetic process; positive regulation of transcription, DNA-dependent

Research Articles on SEC14L2

1. novel association between the rs737723 polymorphism (SEC14L2/TAP) and higher primary open-angle glaucoma risk

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SEC14L2 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>13 publications with SEC14L2 and Neoplasms
Breast Neoplasms Antibodies	>5 publications with SEC14L2 and Breast Neoplasms
Genital Diseases, Male Antibodies	>4 publications with SEC14L2 and Genital Diseases, Male
Prostatic Diseases Antibodies	>4 publications with SEC14L2 and Prostatic Diseases
Liver Neoplasms Antibodies	>4 publications with SEC14L2 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with SEC14L2 and Carcinoma, Hepatocellular
Liver Diseases Antibodies	>2 publications with SEC14L2 and Liver Diseases
Neoplasms, Experimental Antibodies	>1 publications with SEC14L2 and Neoplasms, Experimental
Death Antibodies	>1 publications with SEC14L2 and Death
Inflammation Antibodies	>1 publications with SEC14L2 and Inflammation

Organs/Tissues associated with anti-SEC14L2 antibody

Organ/Tissue Name	Pubmed Publications
Prostate Antibodies	>9 publications with SEC14L2 and Prostate
Liver Antibodies	>8 publications with SEC14L2 and Liver
Blood Antibodies	>5 publications with SEC14L2 and Blood
Brain Antibodies	>3 publications with SEC14L2 and Brain
Lung Antibodies	>2 publications with SEC14L2 and Lung
Ovary Antibodies	>1 publications with SEC14L2 and Ovary
Umbilical Cord Antibodies	>1 publications with SEC14L2 and Umbilical Cord
Lymph Node Antibodies	>1 publications with SEC14L2 and Lymph Node
Testis Antibodies	>1 publications with SEC14L2 and Testis
Intestine Antibodies	>1 publications with SEC14L2 and Intestine