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WRAP53 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005608

MBS6005608 is an antibody targeting WRAP53. Also known as WRAP53 (WD40 Repeat-containing Protein Encoding RNA Antisense to p53, Telomerase Cajal Body Protein 1, TCAB1, WD Repeat-containing Protein 79, WDR79, DKCB3). Reactive in Human. Host: Mouse. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
WRAP53, Monoclonal Antibody
Full Product Name
WRAP53 (WD40 Repeat-containing Protein Encoding RNA Antisense to p53, Telomerase Cajal Body Protein 1, TCAB1, WD Repeat-containing Protein 79, WDR79, DKCB3)
Product Gene Name
anti-WRAP53 antibody
Product Synonym Names
Anti -WRAP53 (WD40 Repeat-containing Protein Encoding RNA Antisense to p53, Telomerase Cajal Body Protein 1, TCAB1, WD Repeat-containing Protein 79, WDR79, DKCB3)
Immunogen Sequence
AVSQELREGD PVSLSTPLET EFGSPSELSP RIEEQELSEN TSLPAEEANG SLSEEEANGP ELGSGKAMED TSGEPAAEDE GDTAWNYSFS QLPRFLSGS
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
1F12
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human WDR79.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
59,309 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (7589389..7606820). Location: 17p13.1
OMIM
612661
3D Structure
ModBase 3D Structure for Q9BUR4
Immunogen
Partial recombinant corresponding to aa62-161 from human WDR79 (NP_060551) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-WRAP53 antibody

Antibodies; Abs to WD Repeat Proteins
Applications Tested/Suitable for anti-WRAP53 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-WRAP53 antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-WRAP53 antibody

Western Blot detection against Immunogen (37kD).
Mouse Anti-WRAP53 Monoclonal Antibody – Cat# MBS6005608

Western Blot (WB) of anti-WRAP53 antibody

WDR79 monoclonal antibody. Western Blot analysis of WDR79 expression in A-431.
Mouse Anti-WRAP53 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6005608

Testing Data of anti-WRAP53 antibody

Detection limit for recombinant GST tagged WDR79 is 0.03ng/ml as a capture antibody.
Mouse Anti-WRAP53 Monoclonal Antibody, Testing Data – Cat# MBS6005608

Other Notes

Small volumes of anti-WRAP53 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for WRAP53. It may not necessarily be applicable to this product.

NCBI GI #
59726941
NCBI GeneID
55135
NCBI Accession #
AAW92115.1
UniProt Primary Accession #
Q9BUR4
UniProt Secondary Accession #
Q08ET9; Q9NW09; B3KPR9; D3DTQ4
UniProt Related Accession #
Q9BUR4
NCBI Official Full Name
WRAP53
NCBI Official Synonym Full Names
WD repeat containing, antisense to TP53
NCBI Official Symbol
WRAP53
NCBI Official Synonym Symbols
DKCB3; TCAB1; WDR79
UniProt Protein Name
Telomerase Cajal body protein 1
UniProt Synonym Protein Names
WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53
Protein Family
Telomerase Cajal body protein
UniProt Gene Name
WRAP53
UniProt Synonym Gene Names
TCAB1; WDR79
UniProt Entry Name
WAP53_HUMAN
NCBI Protein Information
telomerase Cajal body protein 1; WD40 protein Wrap53; WD repeat-containing protein 79; WD40 repeat-containing protein encoding RNA antisense to p53

NCBI Summary for WRAP53

This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
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UniProt Comments for WRAP53

WRAP53: a protein of unknown function. Contains 6 WD40 domains, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: nucleoplasm; Cajal body; cytoplasm; telomerase holoenzyme complex; nucleus

Molecular Function: protein binding; RNA binding

Biological Process: telomere formation via telomerase; positive regulation of telomerase activity

Disease: Dyskeratosis Congenita, Autosomal Recessive, 3
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Research Articles on WRAP53

1. Examined expression of WRAP53 protein in rectal cancers and analyzed its relationship to the response to preoperative radiotherapy and patient survival.In radiotherapy group, positive WRAP53 in the metastasis correlated with better survival.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-WRAP53 antibody

 Reference Product  PubMed Publications
 DKC1 antibody  >2 publications with WRAP53 and DKC1
 TERT antibody  >2 publications with WRAP53 and TERT

Pathways associated with anti-WRAP53 antibody

 Products by Pathway  Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Chromosome Maintenance Pathway antibodies  Chromosome Maintenance Pathway Diagram
 Extension Of Telomeres Pathway antibodies  Extension Of Telomeres Pathway Diagram
 Telomere Extension By Telomerase Pathway antibodies  Telomere Extension By Telomerase Pathway Diagram
 Telomere Maintenance Pathway antibodies  Telomere Maintenance Pathway Diagram

Diseases associated with anti-WRAP53 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with WRAP53 and Neoplasms
 Atrophy Antibodies  >1 publications with WRAP53 and Atrophy
 Neoplasm Metastasis Antibodies  >1 publications with WRAP53 and Neoplasm Metastasis
 Eye Abnormalities Antibodies  >1 publications with WRAP53 and Eye Abnormalities
 Fibrosis Antibodies  >1 publications with WRAP53 and Fibrosis
 Nervous System Diseases Antibodies  >1 publications with WRAP53 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >1 publications with WRAP53 and Congenital Abnormalities

Organs/Tissues associated with anti-WRAP53 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3 publications with WRAP53 and Blood
 Bone Antibodies  >2 publications with WRAP53 and Bone
 Liver Antibodies  >2 publications with WRAP53 and Liver
 Lymph Node Antibodies  >1 publications with WRAP53 and Lymph Node
 Muscle Antibodies  >1 publications with WRAP53 and Muscle
 Eye Antibodies  >1 publications with WRAP53 and Eye
 Bone Marrow Antibodies  >1 publications with WRAP53 and Bone Marrow
 Lung Antibodies  >1 publications with WRAP53 and Lung
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