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DOCK4 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6005770

Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DOCK4, Monoclonal Antibody
Full Product Name
DOCK4 (Dedicator of Cytokinesis Protein 4, FLJ34238, KIAA0716, MGC134911, MGC134912)
Product Gene Name
anti-DOCK4 antibody
Product Synonym Names
Anti -DOCK4 (Dedicator of Cytokinesis Protein 4, FLJ34238, KIAA0716, MGC134911, MGC134912)
Immunogen Sequence
NQVNEQSAPL PVPVPVPVPS YGGEEPVRKE SKTPPPYSVY ERTLRRPVPL PHSLSIPVTS EPPALPPKPL AARSSHLENG ARRTDPGPRP RPLPRKVSQL
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
3E7
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human DOCK4.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
225,206 Da
Chromosome Location
Chromosome: 7; NC_000007.13 (111366164..111846462, complement). Location: 7q31.1
OMIM
607679
3D Structure
ModBase 3D Structure for Q8N1I0
Immunogen
Partial recombinant corresponding to aa1867-1966 from DOCK4 (NP_055520) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-DOCK4 antibody

Antibodies; Abs to Apoptosis
Applications Tested/Suitable for anti-DOCK4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-DOCK4 antibody
Suitable for use in ELISA, Immunohistochemistry, Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 3ug/ml

Western Blot (WB) of anti-DOCK4 antibody

Western Blot detection against Immunogen (36.74kD).
Mouse Anti-DOCK4 Monoclonal Antibody – Cat# MBS6005770

Western Blot (WB) of anti-DOCK4 antibody

DOCK4 monoclonal antibody . Western Blot analysis of DOCK4 expression in HeLa.
Mouse Anti-DOCK4 Monoclonal Antibody, Western Blot (WB) – Cat# MBS6005770

Immunohistochemistry (IHC) of anti-DOCK4 antibody

Immunoperoxidase of monoclonal antibody to DOCK4 on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3ug/ml]
Mouse Anti-DOCK4 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6005770

Immunofluorescence (IF) of anti-DOCK4 antibody

Immunofluorescence of monoclonal antibody to DOCK4 on HeLa cell. [antibody concentration 10ug/ml.
Mouse Anti-DOCK4 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6005770

Testing Data of anti-DOCK4 antibody

Detection limit for recombinant GST tagged DOCK4 is ~0.1ng/ml as a capture antibody.
Mouse Anti-DOCK4 Monoclonal Antibody, Testing Data – Cat# MBS6005770

Other Notes

Small volumes of anti-DOCK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DOCK4 purchase

MBS6005770 is an antibody targeting DOCK4. Also known as DOCK4 (Dedicator of Cytokinesis Protein 4, FLJ34238, KIAA0716, MGC134911, MGC134912). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for DOCK4. It may not necessarily be applicable to this product.

NCBI GI #
92091572
NCBI GeneID
9732
NCBI Accession #
NP_055520.3
UniProt Primary Accession #
Q8N1I0
UniProt Secondary Accession #
O14584; O94824; Q8NB45
UniProt Related Accession #
Q8N1I0
GenBank Nucleotide #
NM_014705.3
NCBI Official Full Name
dedicator of cytokinesis protein 4
NCBI Official Synonym Full Names
dedicator of cytokinesis 4
NCBI Official Symbol
DOCK4
UniProt Protein Name
Dedicator of cytokinesis protein 4
Protein Family
Dedicator of cytokinesis protein
UniProt Gene Name
DOCK4
UniProt Synonym Gene Names
KIAA0716
UniProt Entry Name
DOCK4_HUMAN
NCBI Protein Information
dedicator of cytokinesis protein 4

NCBI Summary for DOCK4

This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for DOCK4

DOCK4: Involved in regulation of adherens junction between cells. Plays a role in cell migration. Functions as a guanine nucleotide exchange factor (GEF), which activates Rap1 small GTPase by exchanging bound GDP for free GTP. Belongs to the DOCK family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: GEFs, Ras; Motility/polarity/chemotaxis; GEFs; Oncoprotein

Chromosomal Location of Human Ortholog: 7q31.1

Cellular Component: stereocilium; stereocilium bundle; membrane; endomembrane system; cytosol

Molecular Function: protein binding; guanyl-nucleotide exchange factor activity; Rac GTPase binding; receptor tyrosine kinase binding; SH3 domain binding; PDZ domain binding

Biological Process: small GTPase mediated signal transduction
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Research Articles on DOCK4

1. The Atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DOCK4 antibody

 Reference Product  PubMed Publications
 IMMP2L antibody  >3 publications with DOCK4 and IMMP2L
 ELMO2 antibody  >2 publications with DOCK4 and ELMO2
 GRB2 antibody  >2 publications with DOCK4 and GRB2
 PDGFRB antibody  >1 publications with DOCK4 and PDGFRB

Pathways associated with anti-DOCK4 antibody

 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-DOCK4 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with DOCK4 and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with DOCK4 and Nervous System Diseases
 Learning Disorders Antibodies  >3 publications with DOCK4 and Learning Disorders
 Autistic Disorder Antibodies  >2 publications with DOCK4 and Autistic Disorder
 Cell Transformation, Neoplastic Antibodies  >1 publications with DOCK4 and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >1 publications with DOCK4 and Breast Neoplasms
 Disease Models, Animal Antibodies  >1 publications with DOCK4 and Disease Models, Animal

Organs/Tissues associated with anti-DOCK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with DOCK4 and Brain
 Bone Antibodies  >3 publications with DOCK4 and Bone
 Blood Antibodies  >2 publications with DOCK4 and Blood
 Eye Antibodies  >2 publications with DOCK4 and Eye
 Prostate Antibodies  >1 publications with DOCK4 and Prostate
 Vascular Antibodies  >1 publications with DOCK4 and Vascular
 Kidney Antibodies  >1 publications with DOCK4 and Kidney
 Embryonic Tissue Antibodies  >1 publications with DOCK4 and Embryonic Tissue
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