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Plexin A1 (PLXNA1) Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600609

Plexin-A1 is an 1894 amino acid, 200kD type I transmembrane protein that is a member of the Plexin family of semaphorin signal transducers. Plexin-A1 binds the transmembrane Sema6D directly and binds the Class 3 secreted semaphorins indirectly via… More details

$915 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Plexin A1 (PLXNA1), Monoclonal Antibody
Full Product Name
Plexin A1
Product Gene Name
anti-PLXNA1 antibody
Product Synonym Names
Anti -Plexin A1
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
7H233
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS, 5% trehalose. Reconstitute with 1ml sterile, ddH2O or sterile 40-50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes mouse Plexin A1.
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
211,067 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (126707437..126756235). Location: 3q21.3
OMIM
601055
3D Structure
ModBase 3D Structure for Q9UIW2
Immunogen
E. coli-derived recombinant mouse Plexin A1 (aa49-165) Accession # P70206

Product Categories/Family for anti-PLXNA1 antibody

Antibodies; Abs to Plexin; Semaphorin
Applications Tested/Suitable for anti-PLXNA1 antibody
ELISA (EL/EIA), Immunohistochemistry (IHC)
Application Notes for anti-PLXNA1 antibody
Suitable for use in ELISA and Immunohistochemistry.
Dilution: Immunohistochemistry: 10ug/ml

Other Notes

Small volumes of anti-PLXNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNA1 purchase

MBS600609 is an antibody targeting PLXNA1. Also known as Plexin A1. Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNA1. It may not necessarily be applicable to this product.

NCBI GI #
119599757
NCBI GeneID
5361
UniProt Primary Accession #
Q9UIW2
UniProt Related Accession #
Q6ZTY7; Q9NSM6; Q9UIW2
NCBI Official Full Name
plexin A1, isoform CRA_c
NCBI Official Synonym Full Names
plexin A1
NCBI Official Symbol
PLXNA1
NCBI Official Synonym Symbols
NOV; NOVP; PLXN1; PLEXIN-A1; DKFZp761P19121
UniProt Protein Name
Plexin-A1
UniProt Synonym Protein Names
Semaphorin receptor NOV
Protein Family
Plexin
UniProt Gene Name
PLXNA1
UniProt Synonym Gene Names
NOV; PLXN1
UniProt Entry Name
PLXA1_HUMAN
NCBI Protein Information
plexin-A1; plexin 1; OTTHUMP00000215966; semaphorin receptor NOV

UniProt Comments for PLXNA1

PLXNA1: Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm. Interacts directly with NRP1 and NRP2. Interacts with FARP2, RND1 and KDR/VEGFR2. Binding of SEMA3A leads to dissociation of FARP2. Detected in fetal brain, lung, liver and kidney. Belongs to the plexin family.

Protein type: Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: cytoplasm; plasma membrane; integral to membrane; nucleus

Molecular Function: semaphorin receptor activity; receptor activity

Biological Process: axon guidance; regulation of smooth muscle cell migration; multicellular organismal development
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Research Articles on PLXNA1

1. Expression of Plexin A1 in gastric carcinoma was significantly higher than that in normal gastric mucosa.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PLXNA1 antibody

 Reference Product  PubMed Publications
 PLXNB1 antibody  >10 publications with PLXNA1 and PLXNB1
 SEMA6D antibody  >9 publications with PLXNA1 and SEMA6D
 NRP1 antibody  >4 publications with PLXNA1 and NRP1
 RND1 antibody  >2 publications with PLXNA1 and RND1
 FES antibody  >2 publications with PLXNA1 and FES
 RHOD antibody  >1 publications with PLXNA1 and RHOD

Pathways associated with anti-PLXNA1 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CRMPs In Sema3A Signaling Pathway antibodies  CRMPs In Sema3A Signaling Pathway Diagram
 Other Semaphorin Interactions Pathway antibodies  Other Semaphorin Interactions Pathway Diagram
 SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway antibodies  SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Sema3A PAK Dependent Axon Repulsion Pathway antibodies  Sema3A PAK Dependent Axon Repulsion Pathway Diagram
 Semaphorin Interactions Pathway antibodies  Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXNA1 antibody

 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >1 publications with PLXNA1 and Kidney Diseases
 Adenoma Antibodies  >1 publications with PLXNA1 and Adenoma
 Neurodegenerative Diseases Antibodies  >1 publications with PLXNA1 and Neurodegenerative Diseases
 Kidney Neoplasms Antibodies  >1 publications with PLXNA1 and Kidney Neoplasms
 Diabetes Mellitus Antibodies  >1 publications with PLXNA1 and Diabetes Mellitus

Organs/Tissues associated with anti-PLXNA1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >17 publications with PLXNA1 and Brain
 Embryonic Tissue Antibodies  >14 publications with PLXNA1 and Embryonic Tissue
 Blood Antibodies  >10 publications with PLXNA1 and Blood
 Vascular Antibodies  >9 publications with PLXNA1 and Vascular
 Eye Antibodies  >5 publications with PLXNA1 and Eye
 Kidney Antibodies  >5 publications with PLXNA1 and Kidney
 Heart Antibodies  >4 publications with PLXNA1 and Heart
 Bone Antibodies  >3 publications with PLXNA1 and Bone
 Lung Antibodies  >3 publications with PLXNA1 and Lung
 Skin Antibodies  >2 publications with PLXNA1 and Skin
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