8-Oxoguanine Hydrochloride Antibody – Mouse Monoclonal

8-Oxoguanine is a mutagenic oxidative damage product of guanine. Oxidatively damaged base 8-oxoguanine is generated in the DNA of all living organisms due to the presence of reactive oxygen species in cells. DNA damage threatens the health of the genetic information stored in every DNA molecule; however enzymes exist in cells to protect against the mutagenic effect of this lesion. 8-oxoguanine is one of the most abundant and well-characterized DNA lesions generated by oxidative stress. It has been estimated that ~180 guanines are oxidized to 8-oxoG per mammalian cell per day. 8-oxoG is a miscoding lesion that can cause G:C to T:A or T:A to G:C transversion mutations. This lesion accumulates in DNA with age and it has been loosley linked to several cancers and diseases such as Alzheimer's and Parkinson's.

Small volumes of anti-8-Oxoguanine Hydrochloride antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS600614 is an antibody targeting 8-Oxoguanine Hydrochloride. Also known as 8-Oxoguanine Hydrochloride (8-Hydroxyguanine Hydrochloride). Reactive in Human, Monkey. Host: Mouse.