Glucose Regulated Protein 78 Antibody – Mouse Monoclonal

The tetrapeptide, KDEL located at the carboxy-terminal sequences of luminal proteins is a retrieval motif essential for the precise sorting of these proteins along the secretory pathway. The KDEL proteins perform essential functions in the ER related to protein folding as well as assembly. The localization of chaperones and other soluble proteins to the endoplasmic reticulum (ER) is achieved by their continuous retrieval from post-ER compartments by the KDEL receptor (Erd2p) which is a membrane protein localized in the Golgi apparatus. The KDEL receptor has extensive sequence identity to the yeast Erd2p receptor for proteins bearing the tetrapeptide, HDEL, the yeast ER retention signal. Earlier studies using yeast mutants with deleted HDEL receptors had shown that this receptor was essential for retrieval of HDEL proteins and possibly for regulating transport through the Golgi complex. The regulation of transport through the KDEL receptor appears to be similar to many signal transduction processes in which membrane receptors act through a GTPase-activating protein (GAP that promotes hydrolysis of GTP to GDP) or a quanine nucleotide exchange factor (GEP that enhances exchange of GDP for GTP) of key small GTPases to regulate dfferent cellular functions. Recent data demonstrates that the non-catalytic domain of GAP that is essential for GAP activity in vivo, mediates the recruitment of cytosolic GAP to membranes and its interaction with the KDEL receptor. This interaction with the KDEL receptor is critical for GAP to act on ADP-ribosylation factor 1 (ARF1) which is a key regulator of transport in the secretory system.

Small volumes of anti-Glucose Regulated Protein 78 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS600646 is an antibody targeting Glucose Regulated Protein 78. Also known as Glucose Regulated Protein 78 (Grp78, BiP, KDEL). Reactive in Rat, Yeast. Host: Mouse.