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CHD6 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600730

MBS600730 is an antibody targeting CHD6. Also known as CHD6 (Chromodomain Helicase DNA Binding Protein 6, KIAA1335, RIGB). Reactive in Human. Host: Mouse. More details

$850 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CHD6, Monoclonal Antibody
Full Product Name
CHD6 (Chromodomain Helicase DNA Binding Protein 6, KIAA1335, RIGB)
Product Gene Name
anti-CHD6 antibody
Product Synonym Names
Anti -CHD6 (Chromodomain Helicase DNA Binding Protein 6, KIAA1335, RIGB)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C73
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human CHD6.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
305,412 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (40031170..40247133, complement). Location: 20q12
3D Structure
ModBase 3D Structure for Q8TD26
Immunogen
Partial sequence of recombinant full-length protein to human CHD6

Product Categories/Family for anti-CHD6 antibody

Antibodies; Abs to Binding Proteins
Applications Tested/Suitable for anti-CHD6 antibody
Western Blot (WB)
Application Notes for anti-CHD6 antibody
Suitable for use in Western Blotting.
Dilution: Western Blotting: 1:1000-1:2000

Testing Data of anti-CHD6 antibody

Mouse Anti-CHD6 Monoclonal Antibody – Cat# MBS600730

Western Blot (WB) of anti-CHD6 antibody

Detection of human CHD6 by Western blot. Samples: Whole cell lysate (25 μg) from HeLa cells. Predicted molecular weight: 305 kD
Mouse Anti-CHD6 Monoclonal Antibody, Western Blot (WB) – Cat# MBS600730

Immunostaining (IS) of anti-CHD6 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with MBS600730.
Mouse Anti-CHD6 Monoclonal Antibody, Immunostaining (IS) – Cat# MBS600730

Other Notes

Small volumes of anti-CHD6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHD6. It may not necessarily be applicable to this product.

NCBI GI #
29244924
NCBI GeneID
84181
NCBI Accession #
NP_115597.3
UniProt Primary Accession #
Q8TD26
UniProt Secondary Accession #
Q5JYQ0; Q5TGZ9; Q5TH00; Q5TH01; Q8IZR2; Q8WTY0; Q9H4H6; Q9H6D4; Q9NTT7; Q9P2L1
UniProt Related Accession #
Q8TD26
GenBank Nucleotide #
NM_032221.3
NCBI Official Full Name
chromodomain-helicase-DNA-binding protein 6
NCBI Official Synonym Full Names
chromodomain helicase DNA binding protein 6
NCBI Official Symbol
CHD6
NCBI Official Synonym Symbols
CHD5; RIGB; KIAA1335
UniProt Protein Name
Chromodomain-helicase-DNA-binding protein 6
UniProt Synonym Protein Names
ATP-dependent helicase CHD6; Radiation-induced gene B protein
Protein Family
Chromodomain-helicase-DNA-binding protein
UniProt Gene Name
CHD6
UniProt Synonym Gene Names
CHD5; KIAA1335; RIGB
UniProt Entry Name
CHD6_HUMAN
NCBI Protein Information
chromodomain-helicase-DNA-binding protein 6; CHD-6; OTTHUMP00000031013; ATP-dependent helicase CHD6; radiation-induced gene B protein; helicase C-terminal domain- and SNF2 N-terminal domain-containing protein

NCBI Summary for CHD6

Chromosomal DNA of eukaryotic cells is compacted by nuclear proteins to form chromatin, an organized nucleoprotein structure that can inhibit gene expression. Several multisubunit protein complexes exist to remodel the chromatin to allow patterns of cell type-specific gene expression. The protein encoded by this gene is thought to be a core member of one or more of these complexes. The encoded protein, which is a member of the SNF2/RAD54 helicase family, contains two chromodomains, a helicase domain, and an ATPase domain. [provided by RefSeq]
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UniProt Comments for CHD6

CHD-6: may be a transcriptional regulator. Three alternatively spliced isoforms have been described.

Protein type: Helicase; EC 3.6.4.12; DNA-binding

Chromosomal Location of Human Ortholog: 20q12

Cellular Component: nucleoplasm; DNA-directed RNA polymerase II, core complex

Molecular Function: DNA-dependent ATPase activity; DNA binding; ATP-dependent helicase activity; chromatin binding; ATP binding

Biological Process: transcription, DNA-dependent; chromatin modification
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Research Articles on CHD6

1. Both RNA knockdown experiments and mutational analyses of the E2C domain suggest that binding of CHD6 to E8--E2C contributes to the transcriptional repression of the huma papillomavirus E6/E7 oncogene promoter.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHD6 antibody

 Reference Product  PubMed Publications
 NFE2L2 antibody  >1 publications with CHD6 and NFE2L2

Diseases associated with anti-CHD6 antibody

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with CHD6 and Congenital Abnormalities

Organs/Tissues associated with anti-CHD6 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >2 publications with CHD6 and Muscle
 Brain Antibodies  >2 publications with CHD6 and Brain
 Blood Antibodies  >1 publications with CHD6 and Blood
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