Goat Anti-SLC4A8 Polyclonal Antibody – Cat# MBS6007800

SLC4A8 Antibody – Goat Polyclonal

Name: SLC4A8 Antibody; Polyclonal; Goat; MyBioSource
Brand: MyBioSource
SKU: MBS6007800
Price: 610 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6007800

MBS6007800 is an antibody targeting SLC4A8. Also known as SLC4A8 (Electroneutral Sodium Bicarbonate Exchanger 1, Electroneutral Na(+)-Driven Cl-HCO3 Exchanger, Solute Carrier Family 4 Member 8, k-NBC3, KIAA0739, NBC, NBC3, NDCBE1). Reactive in Bovine, Canine,… More details

$610 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SLC4A8, Polyclonal Antibody

Full Product Name

SLC4A8 (Electroneutral Sodium Bicarbonate Exchanger 1, Electroneutral Na(+)-Driven Cl-HCO3 Exchanger, Solute Carrier Family 4 Member 8, k-NBC3, KIAA0739, NBC, NBC3, NDCBE1)

Product Gene Name

anti-SLC4A8 antibody

Product Synonym Names

Anti -SLC4A8 (Electroneutral Sodium Bicarbonate Exchanger 1, Electroneutral Na(+)-Driven Cl-HCO3 Exchanger, Solute Carrier Family 4 Member 8, k-NBC3, KIAA0739, NBC, NBC3, NDCBE1)

Clonality

Polyclonal

Host

Goat

Species Reactivity

Bovine, Canine, Human, Mouse, Rat

Form/Format

Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.3, 0.5% BSA.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes SCL4A8. Species sequence homology: Bovine, canine, human, mouse and rat.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

122,938 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (51785101..51909547). Location: 12q13.13

OMIM

605024

3D Structure

ModBase 3D Structure for Q2Y0W8

Immunogen

Synthetic peptide corresponding to TNLEVKNGVNCEH, from SLC4A8, at the internal region of the protein (NP_001035049.1, NP_004849.2).

Product Categories/Family for anti-SLC4A8 antibody

Antibodies; Abs to Ion Channel

Applications Tested/Suitable for anti-SLC4A8 antibody

ELISA (EL/EIA)

Application Notes for anti-SLC4A8 antibody

Suitable for use in ELISA.
Dilution: ELISA: 1:1000

Other Notes

Small volumes of anti-SLC4A8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC4A8. It may not necessarily be applicable to this product.

NCBI GI #

19684127

NCBI GeneID

9498

NCBI Accession #

AAH25994.1

UniProt Primary Accession #

Q2Y0W8

UniProt Secondary Accession #

O94843; O95233; Q004B4; Q8N3U2; Q8TC60; Q9UKX8; A0MMZ1

UniProt Related Accession #

Q2Y0W8

NCBI Official Full Name

SLC4A8 protein

NCBI Official Synonym Full Names

solute carrier family 4, sodium bicarbonate cotransporter, member 8

NCBI Official Symbol

SLC4A8

NCBI Official Synonym Symbols

NBC3; NDCBE

UniProt Protein Name

Electroneutral sodium bicarbonate exchanger 1

UniProt Synonym Protein Names

Electroneutral Na(+)-driven Cl-HCO3 exchanger; Solute carrier family 4 member 8; k-NBC3

Protein Family

Electroneutral sodium bicarbonate exchanger

UniProt Gene Name

SLC4A8

UniProt Synonym Gene Names

KIAA0739; NBC; NBC3; NDCBE1

UniProt Entry Name

S4A8_HUMAN

NCBI Protein Information

electroneutral sodium bicarbonate exchanger 1; k-NBC3; electroneutral Na(+)-driven Cl-HCO3 exchanger

NCBI Summary for SLC4A8

The protein encoded by this gene is a membrane protein that functions to transport sodium and bicarbonate ions across the cell membrane. The encoded protein is important for pH regulation in neurons. The activity of this protein can be inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

UniProt Comments for SLC4A8

SLC4A8: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1. Plays a major role in pH regulation in neurons. May be involved in cell pH regulation by transporting HCO3(-) from blood to cell. Enhanced expression in severe acid stress could be important for cell survival by mediating the influx of HCO3(-) into the cells. Also mediates lithium-dependent HCO3(-) cotransport. May be regulated by osmolarity. Belongs to the anion exchanger (TC 2.A.31) family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function: inorganic anion exchanger activity; sodium:bicarbonate symporter activity

Biological Process: bicarbonate transport; regulation of intracellular pH; ion transport; transmembrane transport

Research Articles on SLC4A8

1. This study confirmed the presence in human cDNA of mouse NDCBE-like transcripts (human NDCBE-A) and three novel transcripts NDCBE-C, NDCBE-D, and NDCBE-D'.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC4A8 antibody

Products by Pathway	Pathway Diagram
Bicarbonate Transporters Pathway antibodies	Bicarbonate Transporters Pathway Diagram
SLC-mediated Transmembrane Transport Pathway antibodies	SLC-mediated Transmembrane Transport Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram
Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies	Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram

Diseases associated with anti-SLC4A8 antibody

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>1 publications with SLC4A8 and Brain Diseases

Organs/Tissues associated with anti-SLC4A8 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with SLC4A8 and Brain
Kidney Antibodies	>8 publications with SLC4A8 and Kidney
Blood Antibodies	>3 publications with SLC4A8 and Blood
Pancreas Antibodies	>2 publications with SLC4A8 and Pancreas
Nerve Antibodies	>1 publications with SLC4A8 and Nerve
Trachea Antibodies	>1 publications with SLC4A8 and Trachea
Embryonic Tissue Antibodies	>1 publications with SLC4A8 and Embryonic Tissue
Ovary Antibodies	>1 publications with SLC4A8 and Ovary
Testis Antibodies	>1 publications with SLC4A8 and Testis