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CACNA2D2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6008385

This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1,… More details

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Product Overview

Online Datasheet in PDF
Product Name
CACNA2D2, Polyclonal Antibody
Full Product Name
CACNA2D2, ID (CACNA2D2, KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2)
Product Gene Name
anti-Cacna2d2 antibody
Product Synonym Names
Anti -CACNA2D2, ID (CACNA2D2, KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Mouse
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
130,385 Da
Chromosome Location
Chromosome: 9; NC_000075.6 (107399880..107529343). Location: 9 F1; 9 58.02 cM
3D Structure
ModBase 3D Structure for Q6PHS9
Immunogen
CACNA2D2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 642-671 amino acids from the Central region of human CACNA2D2.

Product Categories/Family for anti-Cacna2d2 antibody

Antibodies; Abs to KIAA; orf
Applications Tested/Suitable for anti-Cacna2d2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Cacna2d2 antibody
Suitable for use in Western Blot, Immunohistochemistry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:10-50

Western Blot (WB) of anti-Cacna2d2 antibody

Western Blot analysis in mouse kidney tissue lysate (35ug/lane) using MBS6008385.
Rabbit Anti-CACNA2D2 Polyclonal Antibody – Cat# MBS6008385

Immunohistochemistry (IHC) of anti-Cacna2d2 antibody

Immunohistochemistry staining in formalin-fixed, paraffi-embedded human cerebellum tissue using MBS6008385. Peroxidase-conjugated secondary antibody and DAB staining were used for visualization.
Rabbit Anti-CACNA2D2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6008385

Testing Data of anti-Cacna2d2 antibody

Rabbit Anti-CACNA2D2 Polyclonal Antibody, Testing Data – Cat# MBS6008385

Other Notes

Small volumes of anti-Cacna2d2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cacna2d2 purchase

MBS6008385 is an antibody targeting Cacna2d2. Also known as CACNA2D2, ID (CACNA2D2, KIAA0558, Voltage-dependent calcium channel subunit alpha-2/delta-2, Voltage-gated calcium channel subunit alpha-2/delta-2, Voltage-dependent calcium channel subunit alpha-2-2, Voltage-dependent calcium channel subunit delta-2). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cacna2d2. It may not necessarily be applicable to this product.

NCBI GI #
187957756
NCBI GeneID
56808
NCBI Accession #
AAI58059.1
UniProt Primary Accession #
Q6PHS9
UniProt Secondary Accession #
Q3TPT9; Q3TSS6; Q6REE3; Q8C8R8; Q8CHE9; Q920H5; Q920H6; Q9EQG2; Q9R142; B2RY16
UniProt Related Accession #
Q6PHS9
NCBI Official Full Name
Cacna2d2 protein
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, alpha 2/delta subunit 2
NCBI Official Symbol
Cacna2d2
NCBI Official Synonym Symbols
du; td; a2d2; torpid; Cacna2d; mKIAA0558
UniProt Protein Name
Voltage-dependent calcium channel subunit alpha-2/delta-2
UniProt Synonym Protein Names
Protein ducky; Voltage-gated calcium channel subunit alpha-2/delta-2
Protein Family
Voltage-dependent calcium channel
UniProt Gene Name
Cacna2d2
UniProt Synonym Gene Names
Kiaa0558
UniProt Entry Name
CA2D2_MOUSE
NCBI Protein Information
voltage-dependent calcium channel subunit alpha-2/delta-2; ducky; protein ducky; alpha 2 delta calcium channel subunit; voltage-gated calcium channel subunit alpha-2/delta-2

UniProt Comments for Cacna2d2

CACNA2D2: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Cellular Component: membrane; integral to membrane; voltage-gated calcium channel complex

Molecular Function: voltage-gated calcium channel activity; calcium channel activity; metal ion binding; calcium channel regulator activity; voltage-gated ion channel activity

Biological Process: rhythmic synaptic transmission; transport; calcium ion transport; regulation of multicellular organism growth; ion transport; regulation of calcium ion transport; muscle fiber development; positive regulation of organ growth; neuromuscular junction development
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Research Articles on Cacna2d2

1. all of the alpha(2)delta subunits studied, alpha(2)delta-1, alpha(2)delta-2, and alpha(2)delta-3, show all of the properties expected of glycosylphosphatidylinositol-anchored proteins, both when heterologously expressed and in native tissues.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Cacna2d2 antibody

 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Cardiac Muscle Contraction Pathway antibodies  Cardiac Muscle Contraction Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Inhibition Of Insulin Secretion By Adrenaline/Noradrenaline Pathway antibodies  Inhibition Of Insulin Secretion By Adrenaline/Noradrenaline Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram

Diseases associated with anti-Cacna2d2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with Cacna2d2 and Neoplasms
 Neurologic Manifestations Antibodies  >7 publications with Cacna2d2 and Neurologic Manifestations
 Seizures Antibodies  >7 publications with Cacna2d2 and Seizures
 Epilepsy, Absence Antibodies  >7 publications with Cacna2d2 and Epilepsy, Absence
 Brain Diseases Antibodies  >6 publications with Cacna2d2 and Brain Diseases
 Pain Antibodies  >5 publications with Cacna2d2 and Pain
 Chromosome Aberrations Antibodies  >5 publications with Cacna2d2 and Chromosome Aberrations
 Ataxia Antibodies  >5 publications with Cacna2d2 and Ataxia
 Aneuploidy Antibodies  >2 publications with Cacna2d2 and Aneuploidy
 Kidney Neoplasms Antibodies  >2 publications with Cacna2d2 and Kidney Neoplasms

Organs/Tissues associated with anti-Cacna2d2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >11 publications with Cacna2d2 and Brain
 Spinal Cord Antibodies  >2 publications with Cacna2d2 and Spinal Cord
 Kidney Antibodies  >2 publications with Cacna2d2 and Kidney
 Testis Antibodies  >1 publications with Cacna2d2 and Testis
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