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Ubiquilin (UBQLN1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS600929

Ubiquilin is a recently discovered protein that is involved in early onset Alzheimer's disease. Ubiquilin binds to and promotes aggregation of presenilin proteins. Although the ubiquilin protein contains ubiquitin-like domains, ubiquilin appears to increase… More details

$1030 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Ubiquilin (UBQLN1), Monoclonal Antibody
Full Product Name
Ubiquilin
Product Gene Name
Product Synonym Names
Anti -Ubiquilin
Clonality
Monoclonal
Isotype
IgG1
Clone Number
6A210
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Purity/Purification
Purified
Purified by Protein A chromatography
Specificity
Specific for the human ubiquilin protein. On Western blots, it identifies the target band at ~66kD. Reactivity has been confirmed with 293 cell lysates.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
62,519 Da
Chromosome Location
Chromosome: 9; NC_000009.11 (86274878..86323168, complement). Location: 9q22; 9q21.2-q21.3
OMIM
605046
3D Structure
ModBase 3D Structure for Q9UMX0
Immunogen
Recombinant protein corresponding to the C-terminal region of the human ubiquilin protein
Applications Tested/Suitable for anti-UBQLN1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-UBQLN1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 0.1-1ug/ml
Western Blot: 1-3ug/ml

Other Notes

Small volumes of anti-UBQLN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for UBQLN1 purchase

MBS600929 is an antibody targeting UBQLN1. Also known as Ubiquilin. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for UBQLN1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
ubiquilin
NCBI Official Synonym Full Names
ubiquilin 1
NCBI Official Symbol
UBQLN1
NCBI Official Synonym Symbols
DA41; DSK2; UBQN; XDRP1; PLIC-1; FLJ90054
UniProt Protein Name
Ubiquilin-1
UniProt Synonym Protein Names
Protein linking IAP with cytoskeleton 1
Protein Family
UniProt Gene Name
UBQLN1
UniProt Synonym Gene Names
DA41; PLIC1
UniProt Entry Name
UBQL1_HUMAN
NCBI Protein Information
ubiquilin-1; hPLIC-1; OTTHUMP00000021544; OTTHUMP00000021545; protein linking IAP with cytoskeleton 1

NCBI Summary for UBQLN1

This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for UBQLN1

UBQLN1: Links CD47 to the cytoskeleton. Promotes the surface expression of GABA-A receptors. Promotes the accumulation of uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has no effect on PSEN1 and PSEN2 degradation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 9q22|9q21.2-q21.3

Cellular Component: nucleoplasm; proteasome complex; protein complex; endoplasmic reticulum; perinuclear region of cytoplasm; cytoplasm

Molecular Function: protein domain specific binding; protein binding; kinase binding

Biological Process: regulation of protein ubiquitination
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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