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V-Myb Myeloblastosis Viral Oncogene Homolog (MYBL2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS601021

The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell… More details

$610 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
v-Myb Myeloblastosis Viral Oncogene Homolog (MYBL2), Monoclonal Antibody
Full Product Name
v-Myb Myeloblastosis Viral Oncogene Homolog (avian)-Like 2 (MYBL2, BMYB, MGC15600)
Product Gene Name
anti-MYBL2 antibody
Product Synonym Names
Anti -v-Myb Myeloblastosis Viral Oncogene Homolog (avian)-Like 2 (MYBL2, BMYB, MGC15600)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C225
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human v-Myb Myeloblastosis Viral Oncogene Homolog (avian)-Like 2. Species Crossreactivity: mouse and rat
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
78,764 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (42295709..42345122). Location: 20q13.1
OMIM
601415
3D Structure
ModBase 3D Structure for P10244
Immunogen
Partial sequence of full-length recombinant human v-Myb Myeloblastosis Viral Oncogene Homolog (avian)-Like 2

Product Categories/Family for anti-MYBL2 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-MYBL2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-MYBL2 antibody
Suitable for use in ELISA, Western Blot and Immunocytochemistry.
Dilution: Western Blot: 0.2-2ug/ml
Immunocytochemistry: 2-100ug/ml

Testing Data of anti-MYBL2 antibody

Mouse Anti-MYBL2 Monoclonal Antibody – Cat# MBS601021

Western Blot (WB) of anti-MYBL2 antibody

Detection of MYBL2 by Western blot. Samples: Whole cell lysate from human HEK293 (H, 25ug) , mouse NIH3T3 (M, 25ug) and rat F2408 (R, 25ug) cells.
Mouse Anti-MYBL2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS601021

Immunostaining (IS) of anti-MYBL2 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with MBS601021.
Mouse Anti-MYBL2 Monoclonal Antibody, Immunostaining (IS) – Cat# MBS601021

Other Notes

Small volumes of anti-MYBL2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYBL2 purchase

MBS601021 is an antibody targeting MYBL2. Also known as v-Myb Myeloblastosis Viral Oncogene Homolog (avian)-Like 2 (MYBL2, BMYB, MGC15600). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MYBL2. It may not necessarily be applicable to this product.

NCBI GI #
119596357
NCBI GeneID
4605
UniProt Primary Accession #
P10244
UniProt Secondary Accession #
B2RBS5
UniProt Related Accession #
P10244; Q53F07
NCBI Official Full Name
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
NCBI Official Synonym Full Names
v-myb myeloblastosis viral oncogene homolog (avian)-like 2
NCBI Official Symbol
MYBL2
NCBI Official Synonym Symbols
BMYB; B-MYB; MGC15600
UniProt Protein Name
Myb-related protein B
UniProt Synonym Protein Names
Myb-like protein 2
Protein Family
Myb-related protein
UniProt Gene Name
MYBL2
UniProt Synonym Gene Names
BMYB
UniProt Entry Name
MYBB_HUMAN
NCBI Protein Information
myb-related protein B; OTTHUMP00000031719; myb-like protein 2; v-myb avian myeloblastosis viral oncogene homolog-like 2

UniProt Comments for MYBL2

B-Myb: a transcription factor involved in cell cycle progression. Phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined.

Protein type: DNA-binding; Motility/polarity/chemotaxis; Transcription factor

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: nucleoplasm

Molecular Function: protein binding; chromatin binding; transcription factor activity

Biological Process: transcription, DNA-dependent; regulation of cell cycle; positive regulation of transcription from RNA polymerase II promoter; mitotic cell cycle; G2/M transition of mitotic cell cycle
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Research Articles on MYBL2

1. MYBL2 activation is crucial for human HCC progression. In particular, our data indicate that MYBL2-LIN9 complex integrity contributes to survival of DNA damaged p53(-/-) cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MYBL2 antibody

 Reference Product  PubMed Publications
 CDK2 antibody  >18 publications with MYBL2 and CDK2
 E2F1 antibody  >14 publications with MYBL2 and E2F1
 CCND1 antibody  >13 publications with MYBL2 and CCND1
 RBL1 antibody  >12 publications with MYBL2 and RBL1
 E2F4 antibody  >9 publications with MYBL2 and E2F4
 CCNA2 antibody  >7 publications with MYBL2 and CCNA2
 RBL2 antibody  >6 publications with MYBL2 and RBL2
 LIN9 antibody  >6 publications with MYBL2 and LIN9
 E2F3 antibody  >5 publications with MYBL2 and E2F3
 NCOR1 antibody  >2 publications with MYBL2 and NCOR1

Pathways associated with anti-MYBL2 antibody

 Products by Pathway  Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with anti-MYBL2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >66 publications with MYBL2 and Neoplasms
 Carcinoma Antibodies  >22 publications with MYBL2 and Carcinoma
 Skin Diseases Antibodies  >15 publications with MYBL2 and Skin Diseases
 Breast Neoplasms Antibodies  >14 publications with MYBL2 and Breast Neoplasms
 Death Antibodies  >11 publications with MYBL2 and Death
 Leukemia Antibodies  >10 publications with MYBL2 and Leukemia
 Adenocarcinoma Antibodies  >10 publications with MYBL2 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >9 publications with MYBL2 and Cell Transformation, Neoplastic
 Female Urogenital Diseases Antibodies  >5 publications with MYBL2 and Female Urogenital Diseases
 Leukemia, Myeloid Antibodies  >5 publications with MYBL2 and Leukemia, Myeloid

Organs/Tissues associated with anti-MYBL2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >12 publications with MYBL2 and Blood
 Muscle Antibodies  >10 publications with MYBL2 and Muscle
 Vascular Antibodies  >9 publications with MYBL2 and Vascular
 Bone Antibodies  >8 publications with MYBL2 and Bone
 Liver Antibodies  >8 publications with MYBL2 and Liver
 Testis Antibodies  >6 publications with MYBL2 and Testis
 Prostate Antibodies  >5 publications with MYBL2 and Prostate
 Bone Marrow Antibodies  >4 publications with MYBL2 and Bone Marrow
 Embryonic Tissue Antibodies  >4 publications with MYBL2 and Embryonic Tissue
 Brain Antibodies  >4 publications with MYBL2 and Brain
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