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C-Erbb2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS601031

c-erbB-2 is a receptor tyrosine kinase. It exhibits extracellular domains with two cysteine-rich sequences, and a cytoplasmic tyrosine kinase domain flanked by large hydrophilic tails that carry several tyrosine autophosphorylation sites. Approximately 25% of… More details

$1035 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
c-erbB2, Monoclonal Antibody
Full Product Name
c-erbB2 (HER-2, neu Receptor) (BSA & Azide Free)
Product Synonym Names
Anti -c-erbB2 (HER-2, neu Receptor) (BSA & Azide Free)
Immunogen Sequence
Extracellu lar domain
Clonality
Monoclonal
Isotype
IgG1
Clone Number
3F31
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in 10mM PBS, pH 7.4. Also available with BSA and azide. See C0026-11L
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Reacts with the intact cells,1,2 slightly increases (~2-fold) the tyrosine kinase activity,1 accelerates (~50%) c-erbB-2 turnover,1 and inhibits (~80%) tumorigenic growth in CD1/nude mice of N87 human gastric carcinoma cell line overexpressing c-erbB-2.1 Species Crossreactivity: human. Does not react with mouse and rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at-20 degree C or colder. Aliquots are stable for at least 12 months at-20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
185kD
Immunogen
Intact SKBR-3 breast cancer cells
Cellular Localization
Cell membrane
Positive Control
SKBR-3 cells, or breast carcinomas.
Applications Tested/Suitable for anti-c-erbB2 antibody
Immunoprecipitation (IP), Immunofluorescence (IF)

Other Notes

Small volumes of anti-c-erbB2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for c-erbB2 purchase

MBS601031 is an antibody targeting c-erbB2. Also known as c-erbB2 (HER-2, neu Receptor) (BSA & Azide Free). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for c-erbB2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI Official Full Name
Chain P, Single Chain Fv Of C219 Heavy Chain V101l Mutant In Complex With Synthetic Epitope Peptide
Protein Family

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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