Chondroitin Sulfate Proteoglycan, Brain Core Protein (ACAN) Antibody – Mouse Monoclonal

Function: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage.

Subcellular location: Secreted › extracellular space › extracellular matrix

Domain: Two globular domains, G1 and G2, comprise the N-terminus of the proteoglycan, while another globular region, G3, makes up the C-terminus. G1 contains Link domains and thus consists of three disulfide-bonded loop structures designated as the A, B, B' motifs. G2 is similar to G1. The keratan sulfate (KS) and the chondroitin sulfate (CS) attachment domains lie between G2 and G3.

Post-translational modification: Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides.

Involvement in disease: Note=Defects in ACAN are the cause of nanomelia, a lethal connective tissue disorder affecting cartilage development (chondrodystrophy) characterized by shortened and malformed limbs. Aggrecan is truncated at its C-terminus in the CS-2 binding domain and is not anymore secreted from the chondrocytes.

Sequence similarities: Belongs to the aggrecan/versican proteoglycan family.Contains 1 C-type lectin domain.Contains 1 EGF-like domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.Contains 4 Link domains.Contains 1 Sushi (CCP/SCR) domain.