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KHSRP Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6010890

KHSRP binds to the dendritic targeting element and may play a role in mRNA trafficking (By similarity). It is a part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are… More details

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Product Overview

Online Datasheet in PDF
Product Name
KHSRP, Monoclonal Antibody
Full Product Name
KHSRP (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75)
Product Gene Name
anti-KHSRP antibody
Product Synonym Names
Anti -KHSRP (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75)
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
4C10
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Concentration
0.4mg/ml (lot specific)
Specificity
Recognizes human KHSRP.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 19; NC_000019.9 (6413115..6424822, complement). Location: 19p13.3
OMIM
603445
3D Structure
ModBase 3D Structure for Q92945
Immunogen
Recombinant corresponding to aa151-240 from human KHSRP with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-KHSRP antibody

Antibodies; Abs to RNA Processing
Applications Tested/Suitable for anti-KHSRP antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KHSRP antibody
Suitable for use in ELISA, Western Blot and Immunohistochemistry.
Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml. Requires HIER using sodium citrate buffer pH 6.0
Optimal dilutions to be determined by the researcher.

Immunohistochemistry (IHC) of anti-KHSRP antibody

Immunohistochemistry analysis of Formalin-Fixed, Paraffin-Embedded (FFPE) of human Testis using MBS6010890.
Mouse Anti-KHSRP Monoclonal Antibody – Cat# MBS6010890

Immunohistochemistry (IHC) of anti-KHSRP antibody

Immunohistochemistry analysis of Formalin-Fixed, Paraffin-Embedded (FFPE) human Tonsil using MBS6010890.
Mouse Anti-KHSRP Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6010890

ELISA (EIA) of anti-KHSRP antibody

ELISA analysis: Detection limit for recombinant GST tagged KHSRP is ~0.3ng/ml as a capture antibody.
Mouse Anti-KHSRP Monoclonal Antibody, ELISA (EIA) – Cat# MBS6010890

Other Notes

Small volumes of anti-KHSRP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KHSRP purchase

MBS6010890 is an antibody targeting KHSRP. Also known as KHSRP (KH Type-splicing Regulatory Protein, KSRP, Far Upstream Element-binding Protein 2, FUSE-binding Protein 2, FBP2, FUBP2, MGC99676, p75). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for KHSRP. It may not necessarily be applicable to this product.

NCBI GI #
54648253
NCBI GeneID
8570
NCBI Accession #
AAH85004.1
UniProt Primary Accession #
Q92945
UniProt Secondary Accession #
O00301; Q59EZ9; Q5U4P6; Q9UNT5; Q9UQH5
UniProt Related Accession #
Q92945
NCBI Official Full Name
KHSRP protein
NCBI Official Synonym Full Names
KH-type splicing regulatory protein
NCBI Official Symbol
KHSRP
NCBI Official Synonym Symbols
FBP2; KSRP; FUBP2
UniProt Protein Name
Far upstream element-binding protein 2
UniProt Synonym Protein Names
KH type-splicing regulatory protein; KSRP; p75
Protein Family
Far upstream element-binding protein
UniProt Gene Name
KHSRP
UniProt Synonym Gene Names
FUBP2; FUSE-binding protein 2; KSRP
UniProt Entry Name
FUBP2_HUMAN
NCBI Protein Information
far upstream element-binding protein 2; p75; FUSE binding protein 2; FUSE-binding protein 2; KH type-splicing regulatory protein

NCBI Summary for KHSRP

The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010]

UniProt Comments for KHSRP

KHSRP: an RNA binding and processing protein that binds to the dendritic targeting element and may play a role in mRNA trafficking. Part of a ternary complex that binds to the downstream control sequence (DCS) of the pre-mRNA. Mediates exon inclusion in transcripts that are subject to tissue-specific alternative splicing. May interact with single-stranded DNA from the far-upstream element (FUSE). May activate gene expression. Also involved in degradation of inherently unstable mRNAs that contain AU-rich elements (AREs) in their 3' untranslated regions, possibly by recruiting degradation machinery to ARE-containing mRNAs. Interacts with APC which is part of the apolipoprotein B mRNA editing enzyme complex. The interaction is not required for activity of the catalytic component, APOBEC1, but may confer stability on the complex.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm; membrane; stress granule; cytosol

Molecular Function: mRNA binding; DNA binding

Biological Process: RNA splicing, via transesterification reactions; mRNA transport; transcription, DNA-dependent; regulation of transcription, DNA-dependent; RNA splicing; mRNA catabolic process; gene expression; mRNA processing
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Research Articles on KHSRP

1. KSRP induces enhanced processing of pri- and pre-miR-155 in cystic fibrosis lung epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-KHSRP antibody

 Reference Product  PubMed Publications
 ELAVL1 antibody  >5 publications with KHSRP and ELAVL1
 HNRNPH1 antibody  >1 publications with KHSRP and HNRNPH1
 PARN antibody  >1 publications with KHSRP and PARN

Pathways associated with anti-KHSRP antibody

 Products by Pathway  Pathway Diagram
 Activation Of Genes By ATF4 Pathway antibodies  Activation Of Genes By ATF4 Pathway Diagram
 Destabilization Of MRNA By KSRP Pathway antibodies  Destabilization Of MRNA By KSRP Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 PERK Regulated Gene Expression Pathway antibodies  PERK Regulated Gene Expression Pathway Diagram
 Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway antibodies  Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway Diagram
 Unfolded Protein Response Pathway antibodies  Unfolded Protein Response Pathway Diagram

Diseases associated with anti-KHSRP antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with KHSRP and Neoplasms
 Nervous System Diseases Antibodies  >5 publications with KHSRP and Nervous System Diseases
 Inflammation Antibodies  >4 publications with KHSRP and Inflammation
 Carcinoma Antibodies  >3 publications with KHSRP and Carcinoma
 Liver Neoplasms Antibodies  >2 publications with KHSRP and Liver Neoplasms
 Kidney Diseases Antibodies  >2 publications with KHSRP and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >2 publications with KHSRP and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >1 publications with KHSRP and Cardiovascular Diseases
 Hyperplasia Antibodies  >1 publications with KHSRP and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with KHSRP and Breast Neoplasms

Organs/Tissues associated with anti-KHSRP antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with KHSRP and Brain
 Liver Antibodies  >6 publications with KHSRP and Liver
 Blood Antibodies  >5 publications with KHSRP and Blood
 Nerve Antibodies  >4 publications with KHSRP and Nerve
 Muscle Antibodies  >3 publications with KHSRP and Muscle
 Bone Antibodies  >3 publications with KHSRP and Bone
 Lung Antibodies  >3 publications with KHSRP and Lung
 Kidney Antibodies  >2 publications with KHSRP and Kidney
 Ovary Antibodies  >1 publications with KHSRP and Ovary
 Skin Antibodies  >1 publications with KHSRP and Skin
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