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PYY Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6010994

PYY gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PYY, Polyclonal Antibody
Full Product Name
PYY, CT (PYY, Peptide YY, PYY-I, Peptide tyrosine tyrosine, Peptide YY(3-36), PYY-II)
Product Gene Name
anti-PYY antibody
Product Synonym Names
Anti -PYY, CT (PYY, Peptide YY, PYY-I, Peptide tyrosine tyrosine, Peptide YY(3-36), PYY-II)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
11,145 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (42030101..42081837, complement). Location: 17q21.1
OMIM
600781
3D Structure
ModBase 3D Structure for P10082
Immunogen
PYY antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 67-97 amino acids from the C-terminal region of human PYY.

Product Categories/Family for anti-PYY antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-PYY antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Flow Cytometry (FC/FACS), Immunofluorescence (IF)
Application Notes for anti-PYY antibody
Suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
Immunohistochemistry: 1:50-100
Flow Cytometry: 1:10-50
Immunofluorescence: 1:10-50

Western Blot (WB) of anti-PYY antibody

Western blot analysis of PYY Antibody (C-term) in MCF-7 cell line lysates (35ug/lane).PYY (arrow) was detected using the purified Pab.
Rabbit Anti-PYY Polyclonal Antibody – Cat# MBS6010994

Immunohistochemistry (IHC) of anti-PYY antibody

PYY Antibody (C-term) IHC analysis in formalin fixed and paraffin embedded colon carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the PYY Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PYY Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6010994

Immunofluorescence (IF) of anti-PYY antibody

Confocal immunofluorescent analysis of PYY Antibody (C-term) with MCF-7 cell followed by Alexa Fluor搴?488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Rabbit Anti-PYY Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6010994

Flow Cytometry (FC/FACS) of anti-PYY antibody

PYY Antibody (C-term) flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-PYY Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6010994

Other Notes

Small volumes of anti-PYY antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PYY purchase

MBS6010994 is an antibody targeting PYY. Also known as PYY, CT (PYY, Peptide YY, PYY-I, Peptide tyrosine tyrosine, Peptide YY(3-36), PYY-II). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PYY. It may not necessarily be applicable to this product.

NCBI GI #
49457254
NCBI GeneID
5697
NCBI Accession #
CAG46926.1
UniProt Primary Accession #
P10082
UniProt Secondary Accession #
Q5U5Q6; Q6FGH8
UniProt Related Accession #
P10082
NCBI Official Full Name
PYY
NCBI Official Synonym Full Names
peptide YY
NCBI Official Symbol
PYY
NCBI Official Synonym Symbols
PYY1; PYY-I
UniProt Protein Name
Peptide YY
UniProt Synonym Protein Names
PYY-I; Peptide tyrosine tyrosineCleaved into the following chain:Peptide YY(3-36); Alternative name(s):; PYY-II
Protein Family
Peptide
UniProt Gene Name
PYY
UniProt Synonym Gene Names
PYY
UniProt Entry Name
PYY_HUMAN
NCBI Protein Information
peptide YY; prepro-PYY; peptide tyrosine tyrosine

NCBI Summary for PYY

The protein encoded by this gene is proteolytically processed to release a peptide that inhibits pancreatic secretion and mobility in the gut. Rare variations in this gene could increase susceptibility to obesity. [provided by RefSeq, Jul 2010]

UniProt Comments for PYY

PYY: This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 17q21.1

Cellular Component: extracellular space; extracellular region

Molecular Function: neuropeptide hormone activity; protein binding; G-protein-coupled receptor binding; hormone activity

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; cell-cell signaling; neuropeptide signaling pathway; eating behavior; digestion; regulation of appetite; feeding behavior; cytoskeleton organization and biogenesis; cell motility

Disease: Obesity
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Research Articles on PYY

1. Data suggest that plasma PYY increases more after high-fat meal rather than after high-carbohydrate meal; plasma PYY is not associated with hunger or fullness; plasma PYY is not associated with energy intake.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PYY antibody

 Reference Product  PubMed Publications
 CCK antibody  >214 publications with PYY and CCK
 POMC antibody  >42 publications with PYY and POMC
 SST antibody  >7 publications with PYY and SST
 NPY2R antibody  >6 publications with PYY and NPY2R
 GAL antibody  >3 publications with PYY and GAL
 NPY1R antibody  >3 publications with PYY and NPY1R
 NPY5R antibody  >1 publications with PYY and NPY5R

Pathways associated with anti-PYY antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-PYY antibody

 Disease Name  Pubmed Publications
 Obesity Antibodies  >353 publications with PYY and Obesity
 Weight Loss Antibodies  >148 publications with PYY and Weight Loss
 Gastrointestinal Diseases Antibodies  >113 publications with PYY and Gastrointestinal Diseases
 Weight Gain Antibodies  >78 publications with PYY and Weight Gain
 Insulin Resistance Antibodies  >65 publications with PYY and Insulin Resistance
 Anorexia Antibodies  >51 publications with PYY and Anorexia
 Diabetes Mellitus, Type 2 Antibodies  >47 publications with PYY and Diabetes Mellitus, Type 2
 Carcinoma Antibodies  >44 publications with PYY and Carcinoma
 Hyperinsulinism Antibodies  >41 publications with PYY and Hyperinsulinism
 Inflammation Antibodies  >38 publications with PYY and Inflammation

Organs/Tissues associated with anti-PYY antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >474 publications with PYY and Intestine
 Brain Antibodies  >378 publications with PYY and Brain
 Kidney Antibodies  >63 publications with PYY and Kidney
 Testis Antibodies  >2 publications with PYY and Testis
 Uncharacterized Tissue Antibodies  >1 publications with PYY and Uncharacterized Tissue
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