CITED1 Antibody – Rabbit Polyclonal

CITED1: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. Belongs to the CITED family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: Xq13.1

Cellular Component: cytoplasm; nucleus; cytosol

Molecular Function: protein C-terminus binding; protein binding; protein homodimerization activity; transcription coactivator activity; LBD domain binding; chromatin binding; transcription factor activity

Biological Process: negative regulation of Wnt receptor signaling pathway; response to cAMP; apoptosis; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; nucleocytoplasmic transport; response to insulin stimulus; transforming growth factor beta receptor signaling pathway; melanocyte differentiation; negative regulation of osteoblast differentiation; negative regulation of neuron apoptosis; vasculogenesis; placenta development; transcription, DNA-dependent; embryonic axis specification; positive regulation of transforming growth factor beta receptor signaling pathway; melanin biosynthetic process; regulation of transcription from RNA polymerase II promoter; cell proliferation; pigmentation; response to estrogen stimulus; ureteric bud branching; response to cytokine stimulus; brain development; negative regulation of transcription, DNA-dependent; metanephros development