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RGS1 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6011287

RGS1 is a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120aa motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by… More details

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Product Overview

Online Datasheet in PDF
Product Name
RGS1, Polyclonal Antibody
Full Product Name
RGS1, CT (B-cell Activation Protein BL34, Early Response Protein 1R20, Regulator of G-protein Signaling 1, 1R20, BL34, IER1)
Product Gene Name
anti-RGS1 antibody
Product Synonym Names
Anti -RGS1, CT (B-cell Activation Protein BL34, Early Response Protein 1R20, Regulator of G-protein Signaling 1, 1R20, BL34, IER1)
Clonality
Polyclonal
Host
Goat
Species Reactivity
Human
Form/Format
Supplied as a liquid in TBS, pH 7.3, 0.5% BSA, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human RGS1. Species sequence homology: Mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
23,858 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (192544857..192549159). Location: 1q31
OMIM
600323
3D Structure
ModBase 3D Structure for Q08116
Immunogen
Synthetic peptide corresponding to C-NLLNDLQANSLK of human RGS1 at C-terminal.

Product Categories/Family for anti-RGS1 antibody

Antibodies; Abs to G Proteins
Applications Tested/Suitable for anti-RGS1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-RGS1 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.5-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 2.5ug/ml

Immunohistochemistry (IHC) of anti-RGS1 antibody

Human Small Intestine (formalin-fixed, paraffin-embedded) stained with RGS1 antibody followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Goat Anti-RGS1 Polyclonal Antibody – Cat# MBS6011287

Immunohistochemistry (IHC) of anti-RGS1 antibody

Human Thymus (formalin-fixed, paraffin-embedded) stained with RGS1 antibody followed by biotinylated goat IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.
Goat Anti-RGS1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6011287

Western Blot (WB) of anti-RGS1 antibody

Antibody staining (1ug/ml) of HepG2 lysate (RIPA buffer, 30ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
Goat Anti-RGS1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6011287

Other Notes

Small volumes of anti-RGS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RGS1 purchase

MBS6011287 is an antibody targeting RGS1. Also known as RGS1, CT (B-cell Activation Protein BL34, Early Response Protein 1R20, Regulator of G-protein Signaling 1, 1R20, BL34, IER1). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for RGS1. It may not necessarily be applicable to this product.

NCBI GI #
115387108
NCBI GeneID
5996
NCBI Accession #
NP_002913.3
UniProt Primary Accession #
Q08116
UniProt Secondary Accession #
Q07918; Q9H1W2; B2RDM9; B4DZY0
UniProt Related Accession #
Q08116
GenBank Nucleotide #
NM_002922.3
NCBI Official Full Name
regulator of G-protein signaling 1
NCBI Official Synonym Full Names
regulator of G-protein signaling 1
NCBI Official Symbol
RGS1
NCBI Official Synonym Symbols
1R20; BL34; IER1; IR20
UniProt Protein Name
Regulator of G-protein signaling 1
UniProt Synonym Protein Names
B-cell activation protein BL34; Early response protein 1R20
Protein Family
Regulator of G-protein signaling
UniProt Gene Name
RGS1
UniProt Synonym Gene Names
1R20; BL34; IER1; RGS1
UniProt Entry Name
RGS1_HUMAN
NCBI Protein Information
regulator of G-protein signaling 1; early response protein 1R20; B-cell activation protein BL34; regulator of G-protein signalling 1; immediate-early response 1, B-cell specific

NCBI Summary for RGS1

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
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UniProt Comments for RGS1

RGS1: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. This protein may be involved in the regulation of B-cell activation and proliferation. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 1q31

Cellular Component: cytoplasm; plasma membrane

Molecular Function: calmodulin binding; GTPase activator activity

Biological Process: immune response; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; positive regulation of GTPase activity
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Research Articles on RGS1

1. Elevated RGS1 levels profoundly reduce T cell migration to lymphoid-homing chemokines

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RGS1 antibody

 Reference Product  PubMed Publications
 CXCL13 antibody  >5 publications with RGS1 and CXCL13
 CXCR5 antibody  >3 publications with RGS1 and CXCR5
 CCL19 antibody  >3 publications with RGS1 and CCL19
 CCR7 antibody  >2 publications with RGS1 and CCR7
 GNAI2 antibody  >2 publications with RGS1 and GNAI2
 CCR5 antibody  >1 publications with RGS1 and CCR5
 GNAZ antibody  >1 publications with RGS1 and GNAZ
 GNAO1 antibody  >1 publications with RGS1 and GNAO1

Pathways associated with anti-RGS1 antibody

 Products by Pathway  Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with anti-RGS1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >18 publications with RGS1 and Neoplasms
 Gastrointestinal Diseases Antibodies  >10 publications with RGS1 and Gastrointestinal Diseases
 Cardiovascular Diseases Antibodies  >8 publications with RGS1 and Cardiovascular Diseases
 Carcinoma Antibodies  >7 publications with RGS1 and Carcinoma
 Neoplasm Metastasis Antibodies  >5 publications with RGS1 and Neoplasm Metastasis
 Inflammation Antibodies  >5 publications with RGS1 and Inflammation
 Neoplasms, Experimental Antibodies  >4 publications with RGS1 and Neoplasms, Experimental
 Necrosis Antibodies  >4 publications with RGS1 and Necrosis
 Cell Transformation, Neoplastic Antibodies  >3 publications with RGS1 and Cell Transformation, Neoplastic
 Carcinoma, Squamous Cell Antibodies  >3 publications with RGS1 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-RGS1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >40 publications with RGS1 and Blood
 Heart Antibodies  >10 publications with RGS1 and Heart
 Lymph Node Antibodies  >8 publications with RGS1 and Lymph Node
 Muscle Antibodies  >8 publications with RGS1 and Muscle
 Brain Antibodies  >8 publications with RGS1 and Brain
 Vascular Antibodies  >6 publications with RGS1 and Vascular
 Eye Antibodies  >6 publications with RGS1 and Eye
 Nerve Antibodies  >5 publications with RGS1 and Nerve
 Bone Antibodies  >5 publications with RGS1 and Bone
 Bone Marrow Antibodies  >4 publications with RGS1 and Bone Marrow
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