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PHF21A Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6011332

The PHF21A gene encodes BHC80, a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural… More details

$880 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PHF21A, Monoclonal Antibody
Full Product Name
PHF21A (BHC80, KIAA1696, PHD Finger Protein 21A, BHC80a, BRAF35-HDAC Complex Protein BHC80)
Product Gene Name
anti-PHF21A antibody
Product Synonym Names
Anti -PHF21A (BHC80, KIAA1696, PHD Finger Protein 21A, BHC80a, BRAF35-HDAC Complex Protein BHC80)
Immunogen Sequence
KQTVKSHTET DEKQTESRTI TPPAAPKPKR EENPQKLAFM VSLGLVTHDH LEEIQSKRQE RKRRTTANPV YSGAVFEPER KKSAVTYLNS TMHPGTRKRA
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
5A6
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human PHF21A.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
74,854 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (45950870..46142985, complement). Location: 11p11.2
OMIM
608325
3D Structure
ModBase 3D Structure for Q96BD5
Immunogen
Partial recombinant corresponding to aa331-431 from human PHF21A (NP_057705) with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-PHF21A antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-PHF21A antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-PHF21A antibody
Suitable for use in ELISA and Western Blot.

Western Blot (WB) of anti-PHF21A antibody

Western Blot detection against Immunogen (37.11kD).
Mouse Anti-PHF21A Monoclonal Antibody – Cat# MBS6011332

Testing Data of anti-PHF21A antibody

Detection limit for recombinant GST tagged PHF21A is ~0.3ng/ml as a capture antibody.
Mouse Anti-PHF21A Monoclonal Antibody, Testing Data – Cat# MBS6011332

Other Notes

Small volumes of anti-PHF21A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHF21A purchase

MBS6011332 is an antibody targeting PHF21A. Also known as PHF21A (BHC80, KIAA1696, PHD Finger Protein 21A, BHC80a, BRAF35-HDAC Complex Protein BHC80). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for PHF21A. It may not necessarily be applicable to this product.

NCBI GI #
156546910
NCBI GeneID
51317
NCBI Accession #
NP_057705.3
UniProt Primary Accession #
Q96BD5
UniProt Secondary Accession #
Q6AWA2; Q9C0G7; Q9H8V9; Q9HAK6; Q9NZE9; D3DQP5
UniProt Related Accession #
Q96BD5
GenBank Nucleotide #
NM_016621.3
NCBI Official Full Name
PHD finger protein 21A isoform b
NCBI Official Synonym Full Names
PHD finger protein 21A
NCBI Official Symbol
PHF21A
NCBI Official Synonym Symbols
BHC80; BM-006
UniProt Protein Name
PHD finger protein 21A
UniProt Synonym Protein Names
BHC80a; BRAF35-HDAC complex protein BHC80
Protein Family
PHD finger protein
UniProt Gene Name
PHF21A
UniProt Synonym Gene Names
BHC80; KIAA1696
UniProt Entry Name
PF21A_HUMAN
NCBI Protein Information
PHD finger protein 21A; BHC80a; BRAF35/HDAC2 complex (80 kDa); BRAF35-HDAC complex protein BHC80

UniProt Comments for PHF21A

PHF21A: Component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 11p11.2

Cellular Component: nucleoplasm; histone deacetylase complex

Molecular Function: DNA binding; zinc ion binding; chromatin binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; suckling behavior; negative regulation of transcription from RNA polymerase II promoter; chromatin modification; blood coagulation
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Research Articles on PHF21A

1. we have uncovered evidence that the ID and CFA phenotypes are both caused by haploinsufficiency of a single gene, PHF21A, at 11p11.2.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PHF21A antibody

 Reference Product  PubMed Publications
 HDAC1 antibody  >4 publications with PHF21A and HDAC1
 HDAC2 antibody  >3 publications with PHF21A and HDAC2
 KDM1A antibody  >3 publications with PHF21A and KDM1A
 ING2 antibody  >1 publications with PHF21A and ING2
 RCOR1 antibody  >1 publications with PHF21A and RCOR1
 HMG20B antibody  >1 publications with PHF21A and HMG20B

Pathways associated with anti-PHF21A antibody

 Products by Pathway  Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-PHF21A antibody

 Disease Name  Pubmed Publications
 Neurobehavioral Manifestations Antibodies  >2 publications with PHF21A and Neurobehavioral Manifestations
 Congenital Abnormalities Antibodies  >2 publications with PHF21A and Congenital Abnormalities
 Nervous System Diseases Antibodies  >2 publications with PHF21A and Nervous System Diseases
 Neoplasms Antibodies  >2 publications with PHF21A and Neoplasms

Organs/Tissues associated with anti-PHF21A antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >2 publications with PHF21A and Nerve
 Brain Antibodies  >2 publications with PHF21A and Brain
 Blood Antibodies  >1 publications with PHF21A and Blood
 Muscle Antibodies  >1 publications with PHF21A and Muscle
 Testis Antibodies  >1 publications with PHF21A and Testis
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