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Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6011503

Ca(v) 1.3 alpha1 subunit is a part of the Ca(v) 1.3 voltage-gated Ca2+ channel, which has become of key importance in regulating Ca2+ at excitatory synapses. The Ca(v) 1.3 channel controls neurotransmitter release from inner hair cells, release of insulin in… More details

$750 / 0.1 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Cacna1d (cacna1da), Polyclonal Antibody
Full Product Name
Cacna1d, NT (Voltage-dependent L-type Calcium Channel Subunit alpha-1D, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 2, Rat Brain Class D, RBD, Voltage-gated Calcium Channel Subunit alpha Cav1.3, Cach3, Cacn4, Cacnl1a2, Cchl1a2)
Product Gene Name
anti-cacna1da antibody
Product Synonym Names
Anti -Cacna1d, NT (Voltage-dependent L-type Calcium Channel Subunit alpha-1D, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 2, Rat Brain Class D, RBD, Voltage-gated Calcium Channel Subunit alpha Cav1.3, Cach3, Cacn4, Cacnl1a2, Cchl1a2)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Rat
Form/Format
Supplied as a liquid in 0.1M Tris-glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes rat Ca(v)1.3 alpha1 subunit. Species Crossreactivity
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 11; NC_007122.5 (37634341..37758882, complement). Location: chromosome: 11
Immunogen
Recombinant corresponding to N-terminus of rat Ca(v) 1.3 alpha1 subunit fused to GST-tag.
Positive Control
Human hyperplastic prostate tissue

Product Categories/Family for anti-cacna1da antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-cacna1da antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-cacna1da antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 0.1ug/ml
Immunohistochemistry: 1:200

Other Notes

Small volumes of anti-cacna1da antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for cacna1da purchase

MBS6011503 is an antibody targeting cacna1da. Also known as Cacna1d, NT (Voltage-dependent L-type Calcium Channel Subunit alpha-1D, Calcium Channel, L Type, alpha-1 Polypeptide, Isoform 2, Rat Brain Class D, RBD, Voltage-gated Calcium Channel Subunit alpha Cav1.3, Cach3, Cacn4, Cacnl1a2, Cchl1a2). Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for cacna1da. It may not necessarily be applicable to this product.

NCBI GI #
190337315
NCBI GeneID
403310
NCBI Accession #
AAI63679.1
NCBI Official Full Name
Cacna1d protein
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, L type, alpha 1D subunit, a
NCBI Official Symbol
cacna1da
NCBI Official Synonym Symbols
isl; cacna1d; cav1.3a; si:dz223c6.1; si:dz136d19.3
NCBI Protein Information
voltage-dependent L-type calcium channel subunit alpha-1D; gem; gemini; L-type calcium channel pore subunit isoform 1.3a

UniProt Comments for cacna1da

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1C gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1C subunit play an important role in excitation-contraction coupling in the heart. Binding of calmodulin or CABP1 at the same regulatory sites results in an opposit effects on the channel function.
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Research Articles on cacna1da

1. Mutations in zebrafish cav1.3a underlie the auditory-vestibular defects of gemini (gem) circler mutants. gem mutant hair cells display normal cell viability, afferent synaptogenesis, and peripheral innervation, yet exhibit reduced extracellular potentials

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-cacna1da antibody

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 Vascular Smooth Muscle Contraction Pathway antibodies  Vascular Smooth Muscle Contraction Pathway Diagram
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