Cleaved (PARP) Antibody – Rabbit Polyclonal

PARP, a 116kD nuclear poly (ADP-ribose) polymerase, is a highly conserved nuclear enzyme implicated in DNA repair and in the apoptosis response of cells. This protein can be cleaved by many caspases in vitro and is one of the main cleavage targets of caspase-3 in vivo. The cleavage occurs between ASP214 and Gly 215, which separates PARP's N-terminal DNA binding domain (24kD) from its C-terminal catalytic domain (89kD). It has been shown that cleavage of PARP facilitates cellular disassembly and inhibition of PARP cleavage attenuates apoptosis in vitro.

Small volumes of anti-PARP, Cleaved antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6011643 is an antibody targeting PARP, Cleaved. Also known as PARP, Cleaved (Poly ADP-Ribose Polymerase, ADP Ribosyltransferase NAD+, ADPRT, ADPRT1, NAD(+) ADP Ribosyltransferase 1, pADPRT-1, Poly Adenosine Diphosphate ADP Ribose Polymerase, Poly [ADP-ribose] Polymerase 1, PARP1, PARP-1, Poly (ADP-ribose) Polymerase. Reactive in Human. Host: Rabbit.