WAF1 Antibody – Mouse Monoclonal

Expression of p21WAF1 is induced by wild type, but not mutant, p53 suppressor protein. The p21WAF1 protein binds to cyclin/CDK complexes and inhibits their kinase activity thereby stopping cell cycle progression. Meanwhile, the p21WAF1 protein also binds to PCNA (proliferating cell nuclear antigen) and blocks DNA replication but not the DNA repair process. Evidently, inactivation of p53 disrupts the p53-dependent expression of p21WAF1. p21WAF1is a tumor suppressor involved in the pathogenesis of a variety of malignancies.

Pooled monoclonal mouse IgGs

Small volumes of anti-WAF1, p21 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS601175 is an antibody targeting WAF1, p21. Also known as WAF1, p21 (Wild-type p53-activated Fragment, Cip1, Sdi1, Pic1 Tumor Suppressor Protein). Reactive in Human, Mouse. Host: Mouse.