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ADCK3 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6012748

This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by… More details

$865 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CABC1 (ADCK3), Monoclonal Antibody
Full Product Name
CABC1 (ADCK3, CABC1, Chaperone activity of bc1 complex-like, mitochondrial, aarF domain-containing protein kinase 3)
Product Gene Name
anti-ADCK3 antibody
Product Synonym Names
Anti -CABC1 (ADCK3, CABC1, Chaperone activity of bc1 complex-like, mitochondrial, aarF domain-containing protein kinase 3)
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
216CT7.5.1
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2, 0.1% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Human
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
71,950 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (227084589..227175246). Location: 1q42.13
OMIM
606980
3D Structure
ModBase 3D Structure for Q8NI60
Immunogen
CABC1 Mab is generated from mouse immunized with CABC1 recombinant protein.

Product Categories/Family for anti-ADCK3 antibody

Antibodies; Abs to Tumor Suppressors
Applications Tested/Suitable for anti-ADCK3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-ADCK3 antibody
Suitable for use in Western Blot, Immunofluorescence, ELISA.
Dilution: ELISA: 1:1000
Western Blot: 1:100~250
Immunofluorescence: 1:10~50

Western Blot (WB) of anti-ADCK3 antibody

CABC1 antibody western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the CABC1 antibody detected the CABC1 protein (arrow).
Mouse Anti-ADCK3 Monoclonal Antibody – Cat# MBS6012748

Immunofluorescence (IF) of anti-ADCK3 antibody

Confocal immunofluorescent analysis of CABC1 Antibody with HepG2 cell followed by Alexa Fluor 488-conjugated goat anti-mouse lgG (green). DAPI was used to stain the cell nuclear (blue).
Mouse Anti-ADCK3 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS6012748

Other Notes

Small volumes of anti-ADCK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADCK3 purchase

MBS6012748 is an antibody targeting ADCK3. Also known as CABC1 (ADCK3, CABC1, Chaperone activity of bc1 complex-like, mitochondrial, aarF domain-containing protein kinase 3). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCK3. It may not necessarily be applicable to this product.

NCBI GI #
34147522
NCBI GeneID
56997
NCBI Accession #
NP_064632.2
UniProt Primary Accession #
Q8NI60
UniProt Secondary Accession #
Q5T7A5; Q63HK0; Q8NCJ6; Q9HBQ1; Q9NQ67
UniProt Related Accession #
Q8NI60
GenBank Nucleotide #
NM_020247.4
NCBI Official Full Name
chaperone activity of bc1 complex-like, mitochondrial
NCBI Official Synonym Full Names
aarF domain containing kinase 3
NCBI Official Symbol
ADCK3
NCBI Official Synonym Symbols
COQ8; ARCA2; CABC1; SCAR9; COQ10D4
UniProt Protein Name
Chaperone activity of bc1 complex-like, mitochondrial
UniProt Synonym Protein Names
aarF domain-containing protein kinase 3
UniProt Gene Name
ADCK3
UniProt Synonym Gene Names
CABC1; Chaperone-ABC1-like
UniProt Entry Name
ADCK3_HUMAN
NCBI Protein Information
chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog

UniProt Comments for ADCK3

ADCK3: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. Defects in ADCK3 are the cause of coenzyme Q10 deficiency, primary, type 4 (COQ10D4). An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Belongs to the protein kinase superfamily. ADCK protein kinase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, atypical; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.-; ATYPICAL group; ABC1 family; ABC1-A subfamily

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: mitochondrion

Molecular Function: protein serine/threonine kinase activity; ATP binding

Biological Process: ubiquinone biosynthetic process; protein amino acid phosphorylation

Disease: Coenzyme Q10 Deficiency, Primary, 4
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Research Articles on ADCK3

1. These observations highlight the importance of screening for a potentially treatable cause, CABC1/ADCK3 mutations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ADCK3 antibody

 Disease Name  Pubmed Publications
 Brain Diseases Antibodies  >6 publications with ADCK3 and Brain Diseases
 Nervous System Diseases Antibodies  >6 publications with ADCK3 and Nervous System Diseases
 Seizures Antibodies  >2 publications with ADCK3 and Seizures
 Tremor Antibodies  >1 publications with ADCK3 and Tremor
 Kidney Diseases Antibodies  >1 publications with ADCK3 and Kidney Diseases

Organs/Tissues associated with anti-ADCK3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >5 publications with ADCK3 and Muscle
 Brain Antibodies  >5 publications with ADCK3 and Brain
 Eye Antibodies  >1 publications with ADCK3 and Eye
 Kidney Antibodies  >1 publications with ADCK3 and Kidney
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