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MTDH Antibody – Mouse Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6012763

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a… More details

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Product Overview

Online Datasheet in PDF
Product Name
MTDH, Polyclonal Antibody
Full Product Name
MTDH (Protein LYRIC, 3D3/LYRIC, Astrocyte Elevated gene-1 Protein, AEG-1, Lysine-rich CEACAM1 Co-isolated Protein, Metadherin, Metastasis Adhesion Protein, AEG1, LYRIC)
Product Gene Name
anti-MTDH antibody
Product Synonym Names
Anti -MTDH (Protein LYRIC, 3D3/LYRIC, Astrocyte Elevated gene-1 Protein, AEG-1, Lysine-rich CEACAM1 Co-isolated Protein, Metadherin, Metastasis Adhesion Protein, AEG1, LYRIC)
Immunogen Sequence
MAARSWQDEL AQQAEEGSAR LREMLSVGLG FLRTELGLDL GLEPKRYPGW VILVGTGALG LLLLFLLGYG WAAACAGSRK KRRSPPRKRE EAAAVPAAAP DDLALLKNLR SEEQKKKNRK KLSEKPKPNG RTVEVAEGEA VRTPQSVTAK QPPEIDKKNE KSKKNKKKSK SDAKAVQNSS RHDGKEVDEG AWETKISHRE KRQQRKRDKV LTDSGSLDST IPGIENTITV TTEQLTTASF PVGSKKNKGD SHLNVQVSNF KSGKGDSTLQ VSSGLNENLT VNGGGWNEKS VKLSSQISAG EEKWNSVSPA SAGKRKAEPS AWSQDTGDAN TNGKDWGRSW SDRSIFSGIG STAEPVSQST TSDYQWDVSR NQPYIDDEWS GLNGLSSADP NSDWNAPAEE WGNWVDEERA SLLKSQEPIP DDQKVSDDDK EKGEGALPTG KSKKKKKKKK KQGEDNSTAQ DTEELEKEIR EDLPVNTSKT RPKQEKAFSL KTISTSDPAE VLVKNSQPIK TLPPATSTEP SVILSKSDSD KSSSQVPPIL QETDKSKSNT KQNSVPPSQT KSETSWESPK QIKKKKKARR ET
Clonality
Polyclonal
Isotype
IgG
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human MTDH.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
63,837 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (98656375..98742488). Location: 8q22.1
OMIM
610323
3D Structure
ModBase 3D Structure for Q86UE4
Immunogen
Full length human MTDH, aa1-582 (NP_848927).

Product Categories/Family for anti-MTDH antibody

Antibodies; Abs to Cancer Markers
Applications Tested/Suitable for anti-MTDH antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-MTDH antibody
Suitable for use in Immunofluorescence and Western Blot.
Dilution: Immunofluorescence: 10ug/ml

Western Blot (WB) of anti-MTDH antibody

MTDH polyclonal antibody. Western Blot analysis of MTDH expression in human placenta.
Mouse Anti-MTDH Polyclonal Antibody – Cat# MBS6012763

Western Blot (WB) of anti-MTDH antibody

MTDH polyclonal antibody. Western Blot analysis of MTDH expression in Jurkat.
Mouse Anti-MTDH Polyclonal Antibody, Western Blot (WB) – Cat# MBS6012763

Western Blot (WB) of anti-MTDH antibody

Western Blot analysis of MTDH expression in transfected 293T cell line by MTDH polyclonal antibody. Lane 1: MTDH transfected lysate (64.02kD). Lane 2: Non-transfected lysate.
Mouse Anti-MTDH Polyclonal Antibody, Western Blot (WB) – Cat# MBS6012763

Immunofluorescence (IF) of anti-MTDH antibody

Immunofluorescence of purified antibody to MTDH on HeLa cell. [antibody concentration 10ug/ml].
Mouse Anti-MTDH Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS6012763

Other Notes

Small volumes of anti-MTDH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MTDH purchase

MBS6012763 is an antibody targeting MTDH. Also known as MTDH (Protein LYRIC, 3D3/LYRIC, Astrocyte Elevated gene-1 Protein, AEG-1, Lysine-rich CEACAM1 Co-isolated Protein, Metadherin, Metastasis Adhesion Protein, AEG1, LYRIC). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MTDH. It may not necessarily be applicable to this product.

NCBI GI #
33872575
NCBI GeneID
92140
NCBI Accession #
AAH09324.1
UniProt Primary Accession #
Q86UE4
UniProt Secondary Accession #
Q05DH2; Q52QU9; Q6PK07; Q8TCX3
UniProt Related Accession #
Q86UE4
NCBI Official Full Name
MTDH protein, partial
NCBI Official Synonym Full Names
metadherin
NCBI Official Symbol
MTDH
NCBI Official Synonym Symbols
3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3
UniProt Protein Name
Protein LYRIC
UniProt Synonym Protein Names
3D3/LYRIC; Astrocyte elevated gene-1 protein; AEG-1; Lysine-rich CEACAM1 co-isolated protein; Metadherin; Metastasis adhesion protein
Protein Family
Protein LYRIC
UniProt Gene Name
MTDH
UniProt Synonym Gene Names
AEG1; LYRIC; AEG-1
UniProt Entry Name
LYRIC_HUMAN
NCBI Protein Information
protein LYRIC; 3D3/LYRIC; metastasis adhesion protein; astrocyte elevated gene-1 protein; lysine-rich CEACAM1 co-isolated protein

UniProt Comments for MTDH

Lyric: a protein of unknown function.

Protein type: Nucleolus; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 8q22.1

Cellular Component: nuclear body; intercellular canaliculus; endoplasmic reticulum membrane; nuclear membrane; tight junction; endoplasmic reticulum; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; nucleolus; integral to membrane; nucleus

Molecular Function: NF-kappaB binding; protein binding; transcription coactivator activity; double-stranded RNA binding

Biological Process: positive regulation of protein kinase B signaling cascade; positive regulation of angiogenesis; positive regulation of I-kappaB kinase/NF-kappaB cascade; lipopolysaccharide-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; positive regulation of autophagy; negative regulation of apoptosis; activation of NF-kappaB transcription factor
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Research Articles on MTDH

1. AEG-1 interacted with beta-catenin in CRC cells and AEG-1 expression was closely associated with progression of CRC. AEG-1 might be a potential therapeutic target in CRC.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MTDH antibody

 Reference Product  PubMed Publications
 MYC antibody  >11 publications with MTDH and MYC
 TFCP2 antibody  >1 publications with MTDH and TFCP2
 DPYD antibody  >1 publications with MTDH and DPYD

Pathways associated with anti-MTDH antibody

 Products by Pathway  Pathway Diagram
 Gastric Cancer Network 2 Pathway antibodies  Gastric Cancer Network 2 Pathway Diagram
 Validated Targets Of C-MYC Transcriptional Activation Pathway antibodies  Validated Targets Of C-MYC Transcriptional Activation Pathway Diagram

Diseases associated with anti-MTDH antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >100 publications with MTDH and Neoplasms
 Neoplasm Metastasis Antibodies  >31 publications with MTDH and Neoplasm Metastasis
 Breast Neoplasms Antibodies  >30 publications with MTDH and Breast Neoplasms
 Liver Neoplasms Antibodies  >15 publications with MTDH and Liver Neoplasms
 Liver Diseases Antibodies  >11 publications with MTDH and Liver Diseases
 Brain Diseases Antibodies  >11 publications with MTDH and Brain Diseases
 Nervous System Diseases Antibodies  >10 publications with MTDH and Nervous System Diseases
 Death Antibodies  >9 publications with MTDH and Death
 Cell Transformation, Neoplastic Antibodies  >9 publications with MTDH and Cell Transformation, Neoplastic
 Necrosis Antibodies  >8 publications with MTDH and Necrosis

Organs/Tissues associated with anti-MTDH antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >18 publications with MTDH and Liver
 Lymph Antibodies  >17 publications with MTDH and Lymph
 Lymph Node Antibodies  >15 publications with MTDH and Lymph Node
 Brain Antibodies  >12 publications with MTDH and Brain
 Lung Antibodies  >11 publications with MTDH and Lung
 Prostate Antibodies  >10 publications with MTDH and Prostate
 Vascular Antibodies  >7 publications with MTDH and Vascular
 Blood Antibodies  >7 publications with MTDH and Blood
 Intestine Antibodies  >4 publications with MTDH and Intestine
 Embryonic Tissue Antibodies  >4 publications with MTDH and Embryonic Tissue
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