DOCK2 Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells, predominantly in the peripheral blood leukocytes, and is involved in remodeling of the actin cytoskeleton required for lymphocyte migration, through the activation of RAC. Mice lacking this gene show a severe impairment in the migration and homing of lymphocytes. These mutant mice also exhibited long-term survival of allografts, suggesting that this gene may be a target for controlling transplant rejection. [provided by RefSeq, Oct 2011]

DOCK2: a hematopoietic cell-specific CDM family protein that is indispensable for lymphocyte chemotaxis. Plays a role in T cell receptor-induced activation of Rac2 and IL-2 transcription. Interacts with RAC, CRKL, and CD3-zeta. Association with ELMO1 is critical for DOCK2-mediated Rac activation. Two alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; GAPs; GAPs, Rac/Rho; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: cytoskeleton; membrane; endomembrane system; cytosol

Molecular Function: protein binding; Rac guanyl-nucleotide exchange factor activity; T cell receptor binding

Biological Process: alpha-beta T cell proliferation; formation of immunological synapse; viral reproduction; myeloid dendritic cell activation during immune response; positive regulation of phagocytosis; small GTPase mediated signal transduction; establishment of T cell polarity; chemotaxis; actin cytoskeleton organization and biogenesis; lipid raft polarization; negative thymic T cell selection; regulation of defense response to virus by virus; positive thymic T cell selection

Disease: Immunodeficiency 40