Rat Anti-MDR49 Monoclonal Antibody – Cat# MBS601293

MDR49 Antibody – Rat Monoclonal

Name: MDR49 Antibody; Monoclonal; Rat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS601293
Price: 1300 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS601293

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1,… More details

$1300 / 0.25 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MDR5 (Mdr49), Monoclonal Antibody

Full Product Name

MDR5 (MRP5, Multi Drug Resistance Associated Protein)

Product Gene Name

anti-Mdr49 antibody

Product Synonym Names

Anti -MDR5 (MRP5, Multi Drug Resistance Associated Protein)

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

6D572

Host

Rat

Species Reactivity

Human

Form/Format

Supplied as a liquid in 0.7% BSA, 0.1% sodium azide.

Purity/Purification

Supernatant
Supernatant

Specificity

Recognizes an internal epitope of human MRP5. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP2 (cMOAT) or MRP3.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

142,739 Da

Chromosome Location

Chromosome: 2R; NT_033778.3 (8827828..8833850, complement). Location: 49E1-49E4

3D Structure

ModBase 3D Structure for Q00449

Immunogen

Recombinant human MRP5 (multidrug resistance-associated protein 5) (aa 82-168).

Product Categories/Family for anti-Mdr49 antibody

Antibodies; Abs to Multi Drug Resistance (MDR)

Applications Tested/Suitable for anti-Mdr49 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

Application Notes for anti-Mdr49 antibody

Suitable for use in Flow cytometry, Immunocytochemistry, Immunohistochemistry and Western Blot.
Dilution: Flow Cytometry: Weak, cell permeabilization required.
Immunocytochemistry: 1:20-1:50. Use on acetone fixed cytospin preparations.
Immunohistochemistry (Frozen sections, weak): 1:20. Use on acetone fixed frozen sections followed by incubation with rabbit anti-rat Ig and a monoclonal rat APAAP complex. Alternatively, after incubation with M2825-20B and washing, slides can be incubated with biotinylated rabbit anti-rat Ig and streptavidin conjugated to horseradish peroxidase.
Western Blot: 1:20-1:50

Other Notes

Small volumes of anti-Mdr49 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Mdr49 purchase

MBS601293 is an antibody targeting Mdr49. Also known as MDR5 (MRP5, Multi Drug Resistance Associated Protein). Reactive in Human. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for Mdr49. It may not necessarily be applicable to this product.

NCBI GI #

272432454

NCBI GeneID

36428

NCBI Accession #

ACZ94407.1

UniProt Primary Accession #

Q00449

UniProt Secondary Accession #

Q9V6I6; B5RIT2; C1C3C4

UniProt Related Accession #

Q00449

NCBI Official Full Name

multi drug resistance 49, isoform B

NCBI Official Synonym Full Names

Multi drug resistance 49

NCBI Official Symbol

Mdr49

NCBI Official Synonym Symbols

CG3879; Dm5; DmelCG3879; mdr49; MDR49; MDR5; Mes5; mrd49

UniProt Protein Name

Multidrug resistance protein homolog 49

UniProt Synonym Protein Names

P-glycoprotein 49

Protein Family

Multidrug resistance protein

UniProt Gene Name

Mdr49

UniProt Entry Name

MDR49_DROME

NCBI Protein Information

CG3879 gene product from transcript CG3879-RA; CG3879-PA; CG3879-PB; Mdr49-PA; Mdr49-PB; multi drug resistance 49

UniProt Comments for Mdr49

Catalytic activity: ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location: Membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. [View classification]Contains 2 ABC transmembrane type-1 domains.Contains 2 ABC transporter domains.

Sequence caution: The sequence ACO25636.1 differs from that shown. Reason: Intron retention.

Research Articles on Mdr49

1. mdr49 was expressed in larval tissues under stress conditions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Mdr49 antibody

Products by Pathway	Pathway Diagram
ABC-family Proteins Mediated Transport Pathway antibodies	ABC-family Proteins Mediated Transport Pathway Diagram
Abacavir Transmembrane Transport Pathway antibodies	Abacavir Transmembrane Transport Pathway Diagram
Abacavir Transport And Metabolism Pathway antibodies	Abacavir Transport And Metabolism Pathway Diagram
Bile Acid And Bile Salt Metabolism Pathway antibodies	Bile Acid And Bile Salt Metabolism Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
PPARA Activates Gene Expression Pathway antibodies	PPARA Activates Gene Expression Pathway Diagram
Recycling Of Bile Acids And Salts Pathway antibodies	Recycling Of Bile Acids And Salts Pathway Diagram
Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway antibodies	Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway Diagram

Diseases associated with anti-Mdr49 antibody

Disease Name	Pubmed Publications
Anoxia Antibodies	>2 publications with Mdr49 and Anoxia
Neoplasms Antibodies	>1 publications with Mdr49 and Neoplasms
Fibrosis Antibodies	>1 publications with Mdr49 and Fibrosis

Organs/Tissues associated with anti-Mdr49 antibody

Organ/Tissue Name	Pubmed Publications
Head Antibodies	>1 publications with Mdr49 and Head