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Thymidine Phosphorylase (TYMP) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS601425

In the presence of inorganic orthophosphate, thymidine phosphorylase catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial… More details

$1040 / 0.5 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Thymidine Phosphorylase (Tymp), Monoclonal Antibody
Full Product Name
Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)
Product Gene Name
anti-Tymp antibody
Product Synonym Names
Anti -Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
0.N.568
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in 10mM PBS, pH 7.4, 0.2% BSA, 0.1% sodium azide, before the addition of glycerol to 40%.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human, mouse and rat thymidine phosphorylase.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
55kD (reduced)
Chromosome Location
Chromosome: 15; NC_000081.5 (89202362..89207467, complement). Location: 15 F1; 15 51.6 cM
3D Structure
ModBase 3D Structure for Q99N42
Immunogen
Recombinant full length human thymidine phosphorylase (TP/PD-ECGF) protein.
Cellular Localization
Cytoplasmic and nuclear
Positive Control
HUVEC cells or breast carcinoma

Product Categories/Family for anti-Tymp antibody

Antibodies; Abs to Enzymes; Phosphorylase
Applications Tested/Suitable for anti-Tymp antibody
Immunohistochemistry (IHC), Neutralization
Application Notes for anti-Tymp antibody
Suitable for use in Immunohistochemistry (formalin/ paraffin)., Note: As reported by an independent laboratory, neutralizes enzymatic activity of TP/PD-ECGF.
Dilution: Immunohistochemistry: 1-2ug/ml for 30 minutes at RT. No special treatment is required for immunohistochemical staining of formalin fixed tissues.

Immunohistochemistry (IHC) of anti-Tymp antibody

Immunohistochemistry analysis of formalin-fixed, paraffin-embedded human breast carcinoma stained using MBS601425, followed by peroxidase-conjugate and AEC chromogen. Note nuclear and cytoplasmic staining of tumor cells.
Mouse Anti-TYMP Monoclonal Antibody – Cat# MBS601425

Other Notes

Small volumes of anti-Tymp antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tymp purchase

MBS601425 is an antibody targeting Tymp. Also known as Thymidine Phosphorylase (TYMP, ECGF1, Gliostatin, hPD-ECGF, MNGIE, PDECGF, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase, TP). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Tymp. It may not necessarily be applicable to this product.

NCBI GI #
19923857
NCBI GeneID
72962
NCBI Accession #
NP_612175.1
UniProt Primary Accession #
Q99N42
UniProt Related Accession #
Q99N42
GenBank Nucleotide #
NM_138302.1
NCBI Official Full Name
thymidine phosphorylase
NCBI Official Synonym Full Names
thymidine phosphorylase
NCBI Official Symbol
Tymp
NCBI Official Synonym Symbols
Ecgf1; PDECGF; Pdgfec; PD-ECGF; 2900072D10Rik
UniProt Protein Name
Thymidine phosphorylase
UniProt Synonym Protein Names
TdRPase
Protein Family
Thymidine phosphorylase
UniProt Gene Name
Tymp
UniProt Synonym Gene Names
Ecgf1
UniProt Entry Name
TYPH_MOUSE
NCBI Protein Information
thymidine phosphorylase; TP; tdRPase; gliostatin; platelet derived growth factor, endothelial cell; endothelial cell growth factor 1 (platelet-derived)

UniProt Comments for Tymp

ECGF1: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Homodimer. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Protein type: Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes; Transferase; Phosphorylase; Motility/polarity/chemotaxis; Cytokine; EC 2.4.2.4; DNA replication

Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; thymidine phosphorylase activity; phosphorylase activity; transferase activity, transferring pentosyl groups; pyrimidine-nucleoside phosphorylase activity

Biological Process: organ morphogenesis; pyrimidine base metabolic process; metabolic process; chemotaxis; pyrimidine nucleoside metabolic process
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Research Articles on Tymp

1. Thymidine phosphorylase and UPP1 double knockout mice showed increased thymidine and deoxyuridine in tissues and developed encephalopathy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Tymp antibody

 Products by Pathway  Pathway Diagram
 (deoxy)ribose Phosphate Degradation Pathway antibodies  (deoxy)ribose Phosphate Degradation Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Drug Metabolism - Other Enzymes Pathway antibodies  Drug Metabolism - Other Enzymes Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Catabolism Pathway antibodies  Pyrimidine Catabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram

Diseases associated with anti-Tymp antibody

 Disease Name  Pubmed Publications
 Mitochondrial Diseases Antibodies  >18 publications with Tymp and Mitochondrial Diseases
 Muscular Diseases Antibodies  >12 publications with Tymp and Muscular Diseases
 Central Nervous System Diseases Antibodies  >12 publications with Tymp and Central Nervous System Diseases
 Neoplasms Antibodies  >8 publications with Tymp and Neoplasms
 Cachexia Antibodies  >8 publications with Tymp and Cachexia
 Carcinoma Antibodies  >4 publications with Tymp and Carcinoma
 Vomiting Antibodies  >4 publications with Tymp and Vomiting
 Pain Antibodies  >3 publications with Tymp and Pain
 Hearing Loss Antibodies  >3 publications with Tymp and Hearing Loss
 Adenocarcinoma Antibodies  >3 publications with Tymp and Adenocarcinoma

Organs/Tissues associated with anti-Tymp antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with Tymp and Brain
 Liver Antibodies  >4 publications with Tymp and Liver
 Skin Antibodies  >2 publications with Tymp and Skin
 Eye Antibodies  >2 publications with Tymp and Eye
 Intestine Antibodies  >1 publications with Tymp and Intestine
 Lung Antibodies  >1 publications with Tymp and Lung
 Inner Ear Antibodies  >1 publications with Tymp and Inner Ear
 Mammary Gland Antibodies  >1 publications with Tymp and Mammary Gland
 Embryonic Tissue Antibodies  >1 publications with Tymp and Embryonic Tissue
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