Nucleoprotein Interactor-1, Hsrp-1 Antibody – Mouse Monoclonal

Protein transfer into and out of the nucleus occurs through the nuclear pore complex (NPCs). Karyopherin, a cytosolic, heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex. NPI-1 (nucleoprotein interactor-1, hSRP-1) is the alpha subunit of karyopherin, which acts as the receptor for the targeted protein's nuclear localization signal. Both subunits of karyopherin are required for protein docking at the NPC; the alpha subunit binds the substrate and the beta subunit acts as an adaptor. Two other proteins, p10 and the GTPase Ran, are also required for the translocation of docked proteins to the nucleus. The karyopherin dimer dissociates during import, a process mediated by RanGTP, which binds to karyopherin beta and promotes the release of both subunits from the docking site. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC.

Small volumes of anti-Nucleoprotein Interactor-1, hSRP-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS601602 is an antibody targeting Nucleoprotein Interactor-1, hSRP-1. Also known as Nucleoprotein Interactor-1, hSRP-1 (NPI-1). Reactive in Human. Host: Mouse.