Contactin 2 (CNTN2) Antibody – Mouse Monoclonal

The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. It may also be involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. [provided by RefSeq]

CNTN2: May play a role in the initial growth and guidance of axons. May be involved in cell adhesion. Belongs to the immunoglobulin superfamily. Contactin family.

Protein type: Membrane protein, GPI anchor; Cell adhesion

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: voltage-gated potassium channel complex; cell surface; cell soma; integral to plasma membrane; plasma membrane; synapse; myelin sheath

Molecular Function: identical protein binding; protein self-association; carbohydrate binding; glycoprotein binding

Biological Process: axon guidance; cerebral cortex GABAergic interneuron migration; myelination in the central nervous system; positive regulation of adenosine receptor signaling pathway; axonal fasciculation; regulation of astrocyte differentiation; learning; microtubule cytoskeleton organization and biogenesis; adult walking behavior; negative regulation of neuron differentiation; receptor internalization; clustering of voltage-gated potassium channels; regulation of axon diameter; cell adhesion; regulation of neuronal synaptic plasticity

Disease: Epilepsy, Familial Adult Myoclonic, 5