Fas, Neutralizing Antibody – Mouse Monoclonal

Apoptosis or programmed-cell death is a physiological process essential for the normal development and maintenance of homeostasis in many organisms. This "cellular suicide" can be mediated by the Fas antigen (CD95, APO1). Fas antigen is a cell-surface glycoprotein (40-50kD). It belongs to the nerve growth factor/tumor necrosis factor (TNF) receptor family. Mice carrying the lymphoproliferation (lpr) mutation develop lymphoadenopathy and suffer from a systematic lupus erythematosus-like autoimmune disease. This mutation is a defect in the Fas gene. Fas is expressed in several tissues including blood, where it expression is upregulated on activated T and B lymphocytes and natural killer cells.

Small volumes of anti-Fas, Neutralizing antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS601701 is an antibody targeting Fas, Neutralizing. Also known as Fas, Neutralizing (CD95, APO-1). Reactive in Human. Host: Mouse.