Nuclear Protein, Ataxia-Telangiectasia Locus (NPAT) Antibody – Mouse Monoclonal

NPAT: nuclear protein of the ATM locus is required for progression through the G1 and S phases of the cell cycle and for S phase entry. Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with MIZF. Also positively regulates the ATM, MIZF and DNA-PK promoters. Transcriptional activation may be accomplished at least in part by the recruitment of the NuA4 histone acetyltransferase (HAT) complex to target gene promoters. Induced by the expression of E2F1, E2F2, E2F3 and E2F4. Expression is reduced in response to radiation-induced DNA damage. Expression peaks at the G1/S phase boundary and declines during S phase. Interacts with the cylin/CDK complexes CCNE1/CDK2 and CCNA1/CDK2. Interacts with BZW1, CASP8AP2, CREBBP, MIZF and YY1. Interacts with the RUVBL1, RUVBL2 and TRRAP subunits of the NuA4 complex. May also interact with GAPDH, NME1, NME2 and STIP1. Belongs to the NPAT family.

Protein type: Transcription regulation; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q22-q23

Cellular Component: nucleoplasm; Cajal body; cytoplasm; nucleus

Molecular Function: protein C-terminus binding; protein binding; transcription coactivator activity; protein N-terminus binding; transcription corepressor activity

Biological Process: G1/S-specific transcription in mitotic cell cycle; transcription, DNA-dependent; regulation of gene expression; positive regulation of transcription, DNA-dependent