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Vasohibin (VASH1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS601886

Vasohibin is an endothelium-derived negative feedback regulator of angiogenesis. The 365 aa, 44kD human Vasohibin shows 93% aa identity with mouse Vasohibin. Vasohibin has no canonical signal sequence, but the full-length form is only associated with cells,… More details

$955 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Vasohibin (VASH1), Monoclonal Antibody
Full Product Name
Vasohibin
Product Gene Name
anti-VASH1 antibody
Product Synonym Names
Anti -Vasohibin
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
8H175
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a lyophilized powder in PBS, 5% trehalose. Reconstitute with 200ul sterile 40-50% glycerol, PBS.
Purity/Purification
Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Vasohibin.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Reconstitute to nominal volume by adding sterile 40-50% glycerol, aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
40,957 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (77228235..77249363). Location: 14q24.3
OMIM
609011
3D Structure
ModBase 3D Structure for Q7L8A9
Immunogen
NS0-derived rhVasohibin. (aa 2 - 365)

Product Categories/Family for anti-VASH1 antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-VASH1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-VASH1 antibody
Suitable for use in Direct ELISA and Western Blot.
Dilution: Direct ELISA: 0.5-1.0ug/ml detection limit for rhVasohibin is ~ 1ng/well.
Western Blot: 1-2ug/ml detection limit for rh Vasohibin is ~ 25ng/lane under non-reducing and reducing conditions.

Other Notes

Small volumes of anti-VASH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VASH1 purchase

MBS601886 is an antibody targeting VASH1. Also known as Vasohibin. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for VASH1. It may not necessarily be applicable to this product.

NCBI GI #
30354302
NCBI GeneID
22846
UniProt Primary Accession #
Q7L8A9
UniProt Secondary Accession #
Q96H02; Q9UBF4; Q9Y629
UniProt Related Accession #
Q7L8A9
NCBI Official Full Name
Vasohibin 1
NCBI Official Synonym Full Names
vasohibin 1
NCBI Official Symbol
VASH1
NCBI Official Synonym Symbols
KIAA1036
UniProt Protein Name
Vasohibin-1
Protein Family
Vasohibin
UniProt Gene Name
VASH1
UniProt Synonym Gene Names
KIAA1036; VASH
UniProt Entry Name
VASH1_HUMAN
NCBI Protein Information
vasohibin-1

UniProt Comments for VASH1

VASH1: Angiogenesis inhibitor. Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts. Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. Acts in an autocrine manner. Inhibits artery neointimal formation and macrophage infiltration. Exhibits heparin-binding activity. Belongs to the vasohibin family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: extracellular space; endoplasmic reticulum; apical part of cell; cytoplasm

Biological Process: negative regulation of angiogenesis; negative regulation of endothelial cell proliferation; response to wounding; angiogenesis; negative regulation of blood vessel endothelial cell migration; cell cycle arrest
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Research Articles on VASH1

1. SVBP(CCDC23)acts as a secretory chaperone for VASH1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-VASH1 antibody

 Disease Name  Pubmed Publications
 Female Urogenital Diseases Antibodies  >5 publications with VASH1 and Female Urogenital Diseases
 Vascular Diseases Antibodies  >5 publications with VASH1 and Vascular Diseases
 Cardiovascular Diseases Antibodies  >4 publications with VASH1 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >3 publications with VASH1 and Adenocarcinoma
 Uterine Neoplasms Antibodies  >2 publications with VASH1 and Uterine Neoplasms
 Diabetic Nephropathies Antibodies  >2 publications with VASH1 and Diabetic Nephropathies
 Carcinoma, Ductal, Breast Antibodies  >2 publications with VASH1 and Carcinoma, Ductal, Breast
 Melanoma Antibodies  >2 publications with VASH1 and Melanoma
 Kidney Diseases Antibodies  >2 publications with VASH1 and Kidney Diseases
 Breast Neoplasms Antibodies  >2 publications with VASH1 and Breast Neoplasms

Organs/Tissues associated with anti-VASH1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >28 publications with VASH1 and Vascular
 Blood Antibodies  >15 publications with VASH1 and Blood
 Muscle Antibodies  >5 publications with VASH1 and Muscle
 Eye Antibodies  >5 publications with VASH1 and Eye
 Bone Antibodies  >3 publications with VASH1 and Bone
 Kidney Antibodies  >2 publications with VASH1 and Kidney
 Uterus Antibodies  >1 publications with VASH1 and Uterus
 Skin Antibodies  >1 publications with VASH1 and Skin
 Spleen Antibodies  >1 publications with VASH1 and Spleen
 Embryonic Tissue Antibodies  >1 publications with VASH1 and Embryonic Tissue
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