• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Wolf-Hirschhorn Syndrome Candidate 1-Like 1 (WHSC1L1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602028

This gene encoding NSD3 is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. NSD3 is Histone methyltransferase which preferentially methylates 'Lys-4' and 'Lys-27' of… More details

$655 / 0.1 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1), Monoclonal Antibody
Full Product Name
Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1, FLJ20353, MGC126766, NSD3, pp14328)
Product Gene Name
anti-WHSC1L1 antibody
Product Synonym Names
Anti -Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1, FLJ20353, MGC126766, NSD3, pp14328)
Clonality
Monoclonal
Isotype
IgG2b
Clone Number
8G3
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human NSD3.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
161,613 Da
Chromosome Location
Chromosome: 8; NC_000008.10 (38132560..38239790, complement). Location: 8p11.2
OMIM
607083
3D Structure
ModBase 3D Structure for Q9BZ95
Immunogen
Recombinant human NSD3 (383-660aa).
Hybridoma
F0 myeloma cells with spleen cells from BALB/c mice.

Product Categories/Family for anti-WHSC1L1 antibody

Antibodies; Abs to Disease Markers
Applications Tested/Suitable for anti-WHSC1L1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-WHSC1L1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1,000-1:3,000

Other Notes

Small volumes of anti-WHSC1L1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for WHSC1L1 purchase

MBS602028 is an antibody targeting WHSC1L1. Also known as Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1, FLJ20353, MGC126766, NSD3, pp14328). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for WHSC1L1. It may not necessarily be applicable to this product.

NCBI GI #
109731704
NCBI GeneID
54904
UniProt Primary Accession #
Q9BZ95
UniProt Secondary Accession #
Q1RMD3; Q3B796; Q6ZSA5; Q9BYU8; Q9BYU9; Q9H2M8; Q9H9W9; Q9NXA6; D3DSX1
UniProt Related Accession #
Q8WYV9; Q9BZ95
NCBI Official Full Name
Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Official Synonym Full Names
Wolf-Hirschhorn syndrome candidate 1-like 1
NCBI Official Symbol
WHSC1L1
NCBI Official Synonym Symbols
NSD3; pp14328; FLJ20353; MGC126766; MGC142029; DKFZp667H044
UniProt Protein Name
Histone-lysine N-methyltransferase NSD3
UniProt Synonym Protein Names
Nuclear SET domain-containing protein 3; Protein whistle; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine; Wolf-Hirschhorn syndrome candidate 1-like protein 1
Protein Family
Histone-lysine N-methyltransferase
UniProt Gene Name
WHSC1L1
UniProt Synonym Gene Names
NSD3
UniProt Entry Name
NSD3_HUMAN
NCBI Protein Information
histone-lysine N-methyltransferase NSD3; protein whistle; OTTHUMP00000228478; OTTHUMP00000228479; OTTHUMP00000228480; OTTHUMP00000228487; WHSC1-like protein 1; nuclear SET domain-containing protein 3; WHSC1-like 1 isoform 9 with methyltransferase activity to lysine

NCBI Summary for WHSC1L1

This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced variants have been described. [provided by RefSeq]

UniProt Comments for WHSC1L1

WHSC1L1: is related to the Wolf-Hirschhorn syndrome candidate-1 protein containing PWWP (proline-tryptophan-tryptophan-proline) domains. The function of the protein has not been determined. Two alternatively spliced isoforms have been described.

Protein type: Methyltransferase; Amino Acid Metabolism - lysine degradation; Oncoprotein; EC 2.1.1.43; Histone-binding; Methyltransferase, protein lysine

Chromosomal Location of Human Ortholog: 8p11.2

Cellular Component: nucleoplasm; chromosome; nucleus

Molecular Function: protein binding; zinc ion binding; histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; histone lysine N-methyltransferase activity (H3-K27 specific)

Biological Process: histone methylation; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; histone H3-K4 methylation; negative regulation of transcription, DNA-dependent

Disease: Leukemia, Acute Myeloid
Show more

Research Articles on WHSC1L1

1. Overexpression of WHSC1L1 gene is associated with breast cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-WHSC1L1 antibody

 Products by Pathway  Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram
 Lysine Degradation Pathway antibodies  Lysine Degradation Pathway Diagram

Diseases associated with anti-WHSC1L1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >5 publications with WHSC1L1 and Breast Neoplasms
 Leukemia, Myeloid, Acute Antibodies  >3 publications with WHSC1L1 and Leukemia, Myeloid, Acute
 Adenocarcinoma Antibodies  >2 publications with WHSC1L1 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >2 publications with WHSC1L1 and Cell Transformation, Neoplastic

Organs/Tissues associated with anti-WHSC1L1 antibody

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >4 publications with WHSC1L1 and Lung
 Bone Marrow Antibodies  >2 publications with WHSC1L1 and Bone Marrow
 Blood Antibodies  >2 publications with WHSC1L1 and Blood
 Bone Antibodies  >2 publications with WHSC1L1 and Bone
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000