Mouse Anti-SERPING1 Monoclonal Antibody – Cat# MBS602040

Western Blot shows lysates of human lung tissue and human ovary tissue. PVDF membrane was probed with MBS602040 (1ug/ml) followed by an IgG (HRP) Anti-Mouse IgG Secondary Antibody. A specific band was detected for Serpin G1/C1 Inhibitor at ~100kD (as indicated). This experiment was conducted under reducing conditions and using 25mM Tris, pH 7.4, 0.15M NaCl, 0.1% Tween 20.

SERPING1 Antibody – Mouse Monoclonal

Name: SERPING1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS602040
Price: 1090 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602040

As a member of the serpin superfamily of serine protease inhibitors, SERPING1 is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. In addition, it inhibits plasma kallikrein and… More details

$1090 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SERPING1, Monoclonal Antibody

Full Product Name

SERPING1 (Serine/Cysteine Proteinase Inhibitor, Clade G, Member 1, Complement C1 Inhibitor, C1-INH, HAE1, HAE2)

Product Gene Name

anti-SERPING1 antibody

Product Synonym Names

Anti -SERPING1 (Serine/Cysteine Proteinase Inhibitor, Clade G, Member 1, Complement C1 Inhibitor, C1-INH, HAE1, HAE2)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

7H118

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 200ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human SERPING1. In Western Blot, does not crossreact with recombinant human SERPINA1, -A3, -A4, -A5, -C1, -D1, -E2 or -F1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

14,110 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (57365027..57382326). Location: 11q12-q13.1

3D Structure

ModBase 3D Structure for Q5UGI5

Immunogen

Human plasma-derived SERPING1.

Product Categories/Family for anti-SERPING1 antibody

Antibodies; Abs to Protease Inhibitors

Applications Tested/Suitable for anti-SERPING1 antibody

ELISA (EL/EIA), Western Blot (WB), Immunoprecipitation (IP)

Application Notes for anti-SERPING1 antibody

Suitable for use in Direct ELISA, Western Blot and Immunoprecipitation.
Dilution: Western Blot: 1ug/ml
Immunoprecipitation: 25ug/ml to immunoprecipitate from conditioned cell culture medium spiked with human SERPINGG1.
Optimal dilutions should be determined by the researcher.

Other Notes

Small volumes of anti-SERPING1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPING1 purchase

MBS602040 is an antibody targeting SERPING1. Also known as SERPING1 (Serine/Cysteine Proteinase Inhibitor, Clade G, Member 1, Complement C1 Inhibitor, C1-INH, HAE1, HAE2). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPING1. It may not necessarily be applicable to this product.

NCBI GI #

54300698

NCBI GeneID

710

UniProt Primary Accession #

Q5UGI5

UniProt Related Accession #

P05155; Q5UGI5; Q5UGI6

NCBI Official Full Name

serine/cysteine proteinase inhibitor clade G member 1 splice variant 3

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade G (C1 inhibitor), member 1

NCBI Official Symbol

SERPING1

NCBI Official Synonym Symbols

C1IN; C1NH; HAE1; HAE2; C1INH

UniProt Protein Name

Serine/cysteine proteinase inhibitor clade G member 1 splice variant 3

Protein Family

Plasma protease C1 inhibitor

UniProt Gene Name

SERPING1

UniProt Entry Name

Q5UGI5_HUMAN

NCBI Protein Information

plasma protease C1 inhibitor; serpin G1; OTTHUMP00000197003; OTTHUMP00000197004; OTTHUMP00000197007; OTTHUMP00000235286; OTTHUMP00000235287; C1-inhibiting factor; C1 esterase inhibitor; complement component 1 inhibitor; serine/cysteine proteinase inhibitor clade G member 1

NCBI Summary for SERPING1

This gene encodes a highly glycosylated plasma protein involved in the regulation of the complement cascade. Its protein inhibits activated C1r and C1s of the first complement component and thus regulates complement activation. Deficiency of this protein is associated with hereditary angioneurotic oedema (HANE). Alternative splicing results in multiple transcript variants encoding the same isoform. [provided by RefSeq]

UniProt Comments for SERPING1

SERPING1: a protein protease inhibitor (C1-inhibitor) that forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play an important role in regulating complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Mutations of the SERPING1 gene is associated with adult macular degeneration can also cause hereditary angioedema. Binds to E.coli stcE which allows localization of SERPING1 to cell membranes thus protecting the bacteria against complement-mediated lysis. Belongs to the serpin family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q12.1

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protein binding

Biological Process: negative regulation of complement activation, lectin pathway; platelet activation; fibrinolysis; platelet degranulation; blood circulation; innate immune response; blood coagulation; blood coagulation, intrinsic pathway; complement activation, classical pathway; aging

Disease: Complement Component 4, Partial Deficiency Of; Angioedema, Hereditary, Type I

Research Articles on SERPING1

1. We did not find a significant association between SERPING1 and exudative age-related macular degeneration in our study

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SERPING1 antibody

Reference Product	PubMed Publications
C1S antibody	>11 publications with SERPING1 and C1S
C1R antibody	>7 publications with SERPING1 and C1R
MASP2 antibody	>4 publications with SERPING1 and MASP2
MASP1 antibody	>2 publications with SERPING1 and MASP1

Pathways associated with anti-SERPING1 antibody

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies	Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
Formation Of Platelet Plug Pathway antibodies	Formation Of Platelet Plug Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Intrinsic Pathway antibodies	Intrinsic Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Pertussis Pathway antibodies	Pertussis Pathway Diagram
Platelet Activation Pathway antibodies	Platelet Activation Pathway Diagram

Diseases associated with anti-SERPING1 antibody

Disease Name	Pubmed Publications
Skin Diseases Antibodies	>93 publications with SERPING1 and Skin Diseases
Angioedema Antibodies	>92 publications with SERPING1 and Angioedema
Urticaria Antibodies	>91 publications with SERPING1 and Urticaria
Edema Antibodies	>41 publications with SERPING1 and Edema
Genetic Diseases, Inborn Antibodies	>37 publications with SERPING1 and Genetic Diseases, Inborn
Angioedemas, Hereditary Antibodies	>37 publications with SERPING1 and Angioedemas, Hereditary
Inflammation Antibodies	>17 publications with SERPING1 and Inflammation
Pain Antibodies	>12 publications with SERPING1 and Pain
Hematologic Diseases Antibodies	>10 publications with SERPING1 and Hematologic Diseases
Neoplasms Antibodies	>7 publications with SERPING1 and Neoplasms

Organs/Tissues associated with anti-SERPING1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>55 publications with SERPING1 and Blood
Vascular Antibodies	>16 publications with SERPING1 and Vascular
Skin Antibodies	>16 publications with SERPING1 and Skin
Larynx Antibodies	>9 publications with SERPING1 and Larynx
Heart Antibodies	>5 publications with SERPING1 and Heart
Eye Antibodies	>5 publications with SERPING1 and Eye
Kidney Antibodies	>4 publications with SERPING1 and Kidney
Intestine Antibodies	>4 publications with SERPING1 and Intestine
Muscle Antibodies	>3 publications with SERPING1 and Muscle
Liver Antibodies	>3 publications with SERPING1 and Liver