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Integrin Alphav, Beta5 (ITGB5) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602052

MBS602052 is an antibody targeting ITGB5. Also known as Integrin alphaV, beta5 (PE). Reactive in Chicken, Human. Host: Mouse. More details

$1030 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Integrin alphaV, beta5 (ITGB5), Monoclonal Antibody
Full Product Name
Integrin alphaV, beta5 (PE)
Product Gene Name
anti-ITGB5 antibody
Product Synonym Names
Anti -Integrin alphaV, beta5 (PE)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q1009
Host
Mouse
Species Reactivity
Chicken, Human
Form/Format
Supplied as a liquid in PBS, pH 7.6, 15mg/ml BSA, 0.1% sodium azide. Labeled with PE.
Purity/Purification
Affinity Purified
Purified by Protein A affinity chromatography.
Specificity
Recognizes human integrin aVb5. Species Crossreactivity: Chicken.
Preparation and Storage
May be stored at 4 degree C before opening. DO NOT FREEZE! Stable at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. Stable for at least 12 months at 4 degree C. Freezing R-Phycoerythrin (PE) conjugates will result in a substantial loss of activity.
Molecular Weight
88,054 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (124480795..124606500, complement). Location: 3q21.2
OMIM
147561
3D Structure
ModBase 3D Structure for P18084
Immunogen
Human UCLA P3 cells (lung carcinoma).

Product Categories/Family for anti-ITGB5 antibody

Antibodies; Abs to Integrin
Applications Tested/Suitable for anti-ITGB5 antibody
ELISA (EL/EIA), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-ITGB5 antibody
Suitable for use in the inhibition of attachment of HT29 cells to vitronectin, Inhibition of attachment of carcinoma and melanoma cells to vitronectin, Immunohistochemistry, Immunocytochemistry, Immunoprecipitation, Flow Cytometry and ELISA.
Dilution: Immunocytochemistry: Acetone fixed only; human carcinomas, normal epithelium and keratinocytes.
Immunohistochemistry: Acetone or paraformaldehyde fixed tissues.
Optimal dilution determined by the researcher.

Other Notes

Small volumes of anti-ITGB5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ITGB5. It may not necessarily be applicable to this product.

NCBI GI #
20127446
NCBI GeneID
3693
NCBI Accession #
NP_002204.2
UniProt Primary Accession #
P18084
UniProt Secondary Accession #
B0LPF8; B2RD70
UniProt Related Accession #
P18084
GenBank Nucleotide #
NM_002213.3
NCBI Official Full Name
integrin beta-5
NCBI Official Synonym Full Names
integrin, beta 5
NCBI Official Symbol
ITGB5
UniProt Protein Name
Integrin beta-5
Protein Family
Integrin
UniProt Gene Name
ITGB5
UniProt Entry Name
ITB5_HUMAN
NCBI Protein Information
integrin beta-5

UniProt Comments for ITGB5

ITGB5: Integrin alpha-V/beta-5 is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand. Heterodimer of an alpha and a beta subunit. Beta-5 associates with alpha-V. Interacts with MYO10. Belongs to the integrin beta chain family.

Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 3q21.2

Cellular Component: cell surface; focal adhesion; leading edge; plasma membrane; phagocytic vesicle; receptor complex

Molecular Function: integrin binding; protein binding; receptor activity

Biological Process: integrin-mediated signaling pathway; antigen processing and presentation of peptide antigen via MHC class I; extracellular matrix organization and biogenesis; muscle contraction; cell-matrix adhesion; transforming growth factor beta receptor signaling pathway; stress fiber formation; antigen processing and presentation of exogenous peptide antigen via MHC class I; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
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Research Articles on ITGB5

1. Depletion of integrin beta5 in triple-negative breast carcinoma cells markedly reduced tumor take, growth and tumor angiogenesis, whereas reexpression of integrin beta5 rescued this phenotype; findings show a critical role for integrin beta5 in the tumorigenic potential of breast carcinoma cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ITGB5 antibody

 Reference Product  PubMed Publications
 ITGAV antibody  >5 publications with ITGB5 and ITGAV
 ITGA3 antibody  >3 publications with ITGB5 and ITGA3
 ITGA5 antibody  >3 publications with ITGB5 and ITGA5
 PTK2 antibody  >2 publications with ITGB5 and PTK2
 ITGA1 antibody  >1 publications with ITGB5 and ITGA1
 TLN1 antibody  >1 publications with ITGB5 and TLN1
 VTN antibody  >1 publications with ITGB5 and VTN

Pathways associated with anti-ITGB5 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing-Cross Presentation Pathway antibodies  Antigen Processing-Cross Presentation Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Class I MHC Mediated Antigen Processing & Presentation Pathway antibodies  Class I MHC Mediated Antigen Processing & Presentation Pathway Diagram
 Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway antibodies  Cross-presentation Of Particulate Exogenous Antigens (phagosomes) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram

Diseases associated with anti-ITGB5 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >9 publications with ITGB5 and Neoplasms
 Inflammation Antibodies  >3 publications with ITGB5 and Inflammation
 Neoplasm Metastasis Antibodies  >2 publications with ITGB5 and Neoplasm Metastasis
 Anemia Antibodies  >1 publications with ITGB5 and Anemia
 Breast Neoplasms Antibodies  >1 publications with ITGB5 and Breast Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with ITGB5 and Neoplasms, Experimental
 Lung Diseases Antibodies  >1 publications with ITGB5 and Lung Diseases

Organs/Tissues associated with anti-ITGB5 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with ITGB5 and Blood
 Uterus Antibodies  >4 publications with ITGB5 and Uterus
 Placenta Antibodies  >4 publications with ITGB5 and Placenta
 Vascular Antibodies  >3 publications with ITGB5 and Vascular
 Muscle Antibodies  >2 publications with ITGB5 and Muscle
 Bone Marrow Antibodies  >2 publications with ITGB5 and Bone Marrow
 Stomach Antibodies  >2 publications with ITGB5 and Stomach
 Bone Antibodies  >2 publications with ITGB5 and Bone
 Lung Antibodies  >2 publications with ITGB5 and Lung
 Prostate Antibodies  >1 publications with ITGB5 and Prostate
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