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TNFRSF17 Antibody – Rat Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602082

BCMA is a member of the TNF receptor superfamily. It binds to BAFF and APRIL. BCMA is expressed on mature B-cells and other B-cell lines. It plays an important role in B cell development, function and regulation. BCMA also has the capability to activate… More details

$925 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BCMA (TNFRSF17), Monoclonal Antibody
Full Product Name
BCMA (B Cell Maturation Protein)
Product Gene Name
Product Synonym Names
Anti -BCMA (B Cell Maturation Protein)
Clonality
Monoclonal
Isotype
IgG2a
Clone Number
6D163
Host
Rat
Species Reactivity
Mouse
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Purified by Protein G affinity chromatography from concentrated tissue culture supernatant
Concentration
1mg/mL (lot specific)
Specificity
Recognizes mouse BCMA. Does not crossreact with human BCMA.
Preparation and Storage
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Chromosome Location
Chromosome: 16; NC_000016.9 (12058964..12061925). Location: 16p13.1
OMIM
109545
3D Structure
ModBase 3D Structure for Q02223
Grade
Affinity Purified
Immunogen
Recombinant protein corresponding to aa1-46 from mouse BCMA at the extracellular domain. Swiss/UniProt Accession: O88472

Product Categories/Family for anti-TNFRSF17 antibody

Applications Tested/Suitable for anti-TNFRSF17 antibody
Western Blot (WB), Immunoprecipitation (IP), Flow Cytometry (FC)
Application Notes for anti-TNFRSF17 antibody
Suitable for use in Immunoprecipitation, Flow Cytometry, Western Blot and Functional Application.
Immunoprecipitation: 1:200
Flow Cytometry: 1:1000
Western Blot: 1:1000
Functional Application: Blocks binding of BAFF to mouse BCMA.

Western Blot (WB) of anti-TNFRSF17 antibody

Western Blot analysis using MBS602082.
Lane 1: MW Marker
Lane 2: Mouse BCMA Recombinant Protein
Rat Anti-TNFRSF17 Monoclonal Antibody – Cat# MBS602082

Flow Cytometry (FC) of anti-TNFRSF17 antibody

FC analysis of cells using MBS602082 Method: HEK 293 cells were mock transfected (thin line) or transfected with an expression plasmid coding for mouse BCMA (thick line). Cells (5x10e5) were incubated on ice for 30 min. in 50ul FC buffer (PBS, 5% fetal calf serum, 0.02% azide) containing 1ug/ml of MBS602082. After washing in FC buffer, PE-conjugated antibody to rat IgG was added. Cells were incubated on ice for 30 min., washed and analyzed by flow cytometry.
Rat Anti-TNFRSF17 Monoclonal Antibody, Flow Cytometry (FC) – Cat# MBS602082

Other Notes

Small volumes of anti-TNFRSF17 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFRSF17 purchase

MBS602082 is an antibody targeting TNFRSF17. Also known as BCMA (B Cell Maturation Protein). Reactive in Mouse. Host: Rat.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFRSF17. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
BCMA
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 17
NCBI Official Symbol
TNFRSF17
NCBI Official Synonym Symbols
BCM; BCMA; CD269
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 17
UniProt Synonym Protein Names
B-cell maturation protein
UniProt Gene Name
TNFRSF17
UniProt Synonym Gene Names
BCM; BCMA
UniProt Entry Name
TNR17_HUMAN
NCBI Protein Information
tumor necrosis factor receptor superfamily member 17; OTTHUMP00000160261; B-cell maturation factor; B cell maturation antigen; B-cell maturation protein

NCBI Summary for TNFRSF17

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq]
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UniProt Comments for TNFRSF17

TNFRSF17: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2.

Protein type: Oncoprotein; Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: integral to membrane; plasma membrane; endomembrane system

Molecular Function: receptor activity

Biological Process: cell proliferation; immune system process; multicellular organismal development; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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