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Ventral Anterior Homeobox 2 (VAX2) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602099

MBS602099 is an antibody targeting VAX2. Also known as Ventral Anterior Homeobox 2 (VAX2). Reactive in Human, Mouse. Host: Mouse. More details

$850 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ventral Anterior Homeobox 2 (VAX2), Monoclonal Antibody
Full Product Name
Ventral Anterior Homeobox 2 (VAX2)
Product Gene Name
anti-VAX2 antibody
Product Synonym Names
Anti -Ventral Anterior Homeobox 2 (VAX2)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C355
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Ventral Anterior Homeobox 2.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
30,874 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (71127720..71160576). Location: 2p13
OMIM
604295
3D Structure
ModBase 3D Structure for Q9UIW0
Immunogen
Partial sequence of recombinant full-length protein to human Ventral Anterior Homeobox 2

Product Categories/Family for anti-VAX2 antibody

Antibodies; Abs to Homeobox (HOX)
Applications Tested/Suitable for anti-VAX2 antibody
Western Blot (WB)
Application Notes for anti-VAX2 antibody
Suitable for use in Western Blotting.
Dilution: Western Blotting: 1:1000-1:2000

Testing Data of anti-VAX2 antibody

Mouse Anti-VAX2 Monoclonal Antibody – Cat# MBS602099

Western Blot (WB) of anti-VAX2 antibody

Detection of VAX2 by Western blot. Samples: Whole cell lysate from human A2058 (H, 50 μg) and mouse NIH3T3 (M, 50 μg) cells. Predicted molecular weight: 30 kD
Mouse Anti-VAX2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS602099

Immunostaining (IS) of anti-VAX2 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with anti-VAX2 mAb.
Mouse Anti-VAX2 Monoclonal Antibody, Immunostaining (IS) – Cat# MBS602099

Other Notes

Small volumes of anti-VAX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VAX2. It may not necessarily be applicable to this product.

NCBI GI #
7110735
NCBI GeneID
25806
NCBI Accession #
NP_036608.1
UniProt Primary Accession #
Q9UIW0
UniProt Secondary Accession #
Q53Y33
UniProt Related Accession #
Q9UIW0
GenBank Nucleotide #
NM_012476.2
NCBI Official Full Name
ventral anterior homeobox 2
NCBI Official Synonym Full Names
ventral anterior homeobox 2
NCBI Official Symbol
VAX2
NCBI Official Synonym Symbols
DRES93
UniProt Protein Name
Ventral anterior homeobox 2
Protein Family
Ventral anterior homeobox
UniProt Gene Name
VAX2
UniProt Entry Name
VAX2_HUMAN
NCBI Protein Information
ventral anterior homeobox 2; OTTHUMP00000160128

NCBI Summary for VAX2

This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq]

UniProt Comments for VAX2

VAX2: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. Belongs to the EMX homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: cytoplasm; nucleus

Molecular Function: chromatin DNA binding; sequence-specific DNA binding; transcription factor activity

Biological Process: Wnt receptor signaling pathway; transcription, DNA-dependent; visual perception; axonogenesis; embryonic eye morphogenesis; retina development in camera-type eye; forebrain development; ectoderm development; dorsal/ventral axis specification; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on VAX2

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-VAX2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with VAX2 and Neoplasms
 Infertility, Female Antibodies  >1 publications with VAX2 and Infertility, Female
 Muscular Diseases Antibodies  >1 publications with VAX2 and Muscular Diseases

Organs/Tissues associated with anti-VAX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >31 publications with VAX2 and Eye
 Lung Antibodies  >1 publications with VAX2 and Lung
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