Tubastatin A ((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol- 5(2H)-yl)methyl)benzamide)

Cell-permeable. A potent and selective HDAC6 (histone deacetylase 6) inhibitor. Displays 1093-fold selectivity over HDAC1 (IC50 values of 15nM for HDAC6 vs 16.4uM for HDAC1). Tubastatin A was substantially more selective than the known HDAC6 inhibitor Tubacin at all isozymes except HDAC8. In addition, it displayed over 1000-fold selectivity against all HDAC isoforms excluding HDAC8, where it displayed 54-fold selectivity. Tubastatin A displayed dose-dependent protection against HCA (homocysteic acid)-induced neuronal cell death starting at 5uM with near complete protection at 10uM.

Small volumes of Tubastatin A biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6022606 is a biochemical targeting Tubastatin A. Also known as Tubastatin A ((2-methyl-3,4-dihydro-1H-pyrido[4,3-b]-indol- 5(2H)-yl)methyl)benzamide).