Mouse Anti-RHOB Monoclonal Antibody – Cat# MBS602314

RHOB Antibody – Mouse Monoclonal

Name: RHOB Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS602314
Price: 850 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602314

RhoB mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation.… More details

$850 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RhoB, Monoclonal Antibody

Full Product Name

RhoB (ARH6, ARHB, RHOH6, Ras homolog family member B, ARH6, Aplysia Ras-related homolog 6, ARHB, RhoH6)

Product Gene Name

anti-RHOB antibody

Product Synonym Names

Anti -RhoB (ARH6, ARHB, RHOH6, Ras homolog family member B, ARH6, Aplysia Ras-related homolog 6, ARHB, RhoH6)

Clonality

Monoclonal

Isotype

IgG1

Clone Number

8C288

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a sterile-filtered liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes human RhoB.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

22,123 Da

Chromosome Location

Chromosome: 2; NC_000002.11 (20646835..20649201). Location: 2p24

OMIM

165370

3D Structure

ModBase 3D Structure for P62745

Immunogen

Partial sequence of recombinant full-length protein to human RhoB

Product Categories/Family for anti-RHOB antibody

Antibodies; Abs to Apoptosis

Applications Tested/Suitable for anti-RHOB antibody

Western Blot (WB)

Application Notes for anti-RHOB antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-RHOB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RHOB purchase

MBS602314 is an antibody targeting RHOB. Also known as RhoB (ARH6, ARHB, RHOH6, Ras homolog family member B, ARH6, Aplysia Ras-related homolog 6, ARHB, RhoH6). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for RHOB. It may not necessarily be applicable to this product.

NCBI GI #

4757764

NCBI GeneID

388

NCBI Accession #

NP_004031.1

UniProt Primary Accession #

P62745

UniProt Secondary Accession #

P01121; Q5U0H6; Q7RTN5; Q7RTR9; Q9CUV7; B2R692

UniProt Related Accession #

P62745

GenBank Nucleotide #

NM_004040.2

NCBI Official Full Name

rho-related GTP-binding protein RhoB

NCBI Official Synonym Full Names

ras homolog family member B

NCBI Official Symbol

RHOB

NCBI Official Synonym Symbols

ARH6; ARHB; RHOH6; MST081; MSTP081

UniProt Protein Name

Rho-related GTP-binding protein RhoB

UniProt Synonym Protein Names

Rho cDNA clone 6

Protein Family

Rho-related GTP-binding protein

UniProt Gene Name

RHOB

UniProt Synonym Gene Names

ARH6; ARHB; h6

UniProt Entry Name

RHOB_HUMAN

NCBI Protein Information

rho-related GTP-binding protein RhoB; h6; oncogene RHO H6; rho cDNA clone 6; Aplysia RAS-related homolog 6; ras homolog gene family, member B

UniProt Comments for RHOB

RHOB: a small G protein of the Rho family. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Controls the reorganization of actins into podosomes. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders.

Protein type: G protein, monomeric, Rho; Motility/polarity/chemotaxis; G protein; G protein, monomeric; Tumor suppressor

Chromosomal Location of Human Ortholog: 2p24

Cellular Component: focal adhesion; late endosome membrane; early endosome; plasma membrane; endosome membrane; nucleus; cytosol; cleavage furrow

Molecular Function: GTPase activity; protein binding; GDP binding; GTP binding

Biological Process: platelet activation; axon guidance; transformed cell apoptosis; metabolic process; positive regulation of apoptosis; apoptosis; cytokinesis; Rho protein signal transduction; negative regulation of cell cycle; intracellular protein transport; regulation of small GTPase mediated signal transduction; positive regulation of angiogenesis; small GTPase mediated signal transduction; endosome to lysosome transport; angiogenesis; cell adhesion; blood coagulation

Research Articles on RHOB

1. Data indicate that miR-21 induced the degradation of RhoB mRNA, which led to the depletion of RhoB and the impairment of tight junctions in intestinal epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RHOB antibody

Reference Product	PubMed Publications
VAV2 antibody	>8 publications with RHOB and VAV2
ARHGEF1 antibody	>7 publications with RHOB and ARHGEF1
ARHGDIA antibody	>5 publications with RHOB and ARHGDIA
ROCK2 antibody	>4 publications with RHOB and ROCK2
ARHGEF2 antibody	>3 publications with RHOB and ARHGEF2
VAV1 antibody	>1 publications with RHOB and VAV1
TIAM1 antibody	>1 publications with RHOB and TIAM1
GRLF1 antibody	>1 publications with RHOB and GRLF1
ARHGDIG antibody	>1 publications with RHOB and ARHGDIG

Pathways associated with anti-RHOB antibody

Products by Pathway	Pathway Diagram
Androgen Receptor Signaling Pathway antibodies	Androgen Receptor Signaling Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
G Alpha (12/13) Signalling Events Pathway antibodies	G Alpha (12/13) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPVI-mediated Activation Cascade Pathway antibodies	GPVI-mediated Activation Cascade Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Neural Crest Differentiation Pathway antibodies	Neural Crest Differentiation Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram

Diseases associated with anti-RHOB antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>154 publications with RHOB and Neoplasms
Cell Transformation, Neoplastic Antibodies	>36 publications with RHOB and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>22 publications with RHOB and Breast Neoplasms
Neoplasm Metastasis Antibodies	>21 publications with RHOB and Neoplasm Metastasis
Lung Neoplasms Antibodies	>21 publications with RHOB and Lung Neoplasms
Neoplasms, Experimental Antibodies	>13 publications with RHOB and Neoplasms, Experimental
Brain Diseases Antibodies	>12 publications with RHOB and Brain Diseases
Kidney Diseases Antibodies	>9 publications with RHOB and Kidney Diseases
Inflammation Antibodies	>8 publications with RHOB and Inflammation
Liver Neoplasms Antibodies	>8 publications with RHOB and Liver Neoplasms

Organs/Tissues associated with anti-RHOB antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>65 publications with RHOB and Brain
Blood Antibodies	>56 publications with RHOB and Blood
Vascular Antibodies	>43 publications with RHOB and Vascular
Lung Antibodies	>37 publications with RHOB and Lung
Kidney Antibodies	>31 publications with RHOB and Kidney
Liver Antibodies	>22 publications with RHOB and Liver
Nerve Antibodies	>21 publications with RHOB and Nerve
Bone Antibodies	>21 publications with RHOB and Bone
Heart Antibodies	>17 publications with RHOB and Heart
Skin Antibodies	>12 publications with RHOB and Skin