Ngcam Related Neuronal Cell Adhesion Molecule (NRCAM) Antibody – Mouse Monoclonal

Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]

NRCAM: Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier. Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane; synapse; external side of plasma membrane

Molecular Function: protein binding; ankyrin binding

Biological Process: axon guidance; clustering of voltage-gated sodium channels; central nervous system development; neuron migration; axonal fasciculation; regulation of axon extension; heterotypic cell-cell adhesion; protein localization; cell-cell adhesion; synaptogenesis; axonogenesis; action potential propagation; angiogenesis; positive regulation of neuron differentiation; retinal ganglion cell axon guidance