Protein Kinase Inhibitor H-89 (PKI, N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide) (N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide)

Protein Kinase Inhibitors

KN-04, which closely resembles KN-62 in its chemical structure, exhibits a weak protein kinase inhibition and is useful as a control for KN-62.
KN-62 and KN-04 are useful tools for elucidation of the function of the enzyme in relation to cellular responses.
H-89 and H-88 have a potent and selective inhibitory effect against cyclic AMP-dependent protein kinase (Protein Kinase A).
H-89 is most powerful among various protein kinase A inhibitors.
H-85 closely resembles H-89 in its chemical structure. It is not specific to Protein Kinase A and has similar inhibitory effects on other kinases ; hence this compound can be used as a negative control of H-89.
CKI-7 has a potent inhibitory effect against casein kinase I and a much weaker effect on casein kinase II as well as other protein kinases.
CKI-8, a derivative of CKI-7, is used as an affinity ligand to purify casein kinase I. These newly synthesized compounds should serve as useful tools for elucidating the biological significance of casein kinase I -mediated reactions.
KN-93, a modified type of KN-62, is also a potent and specific inhibitor of Ca++/CaM Kinase II and its solubility in buffered solution is superior to KN-62.
KN-92, which closely resembles KN-93 in its chemical structure, exhibits no inhibitory effect to Ca++/CaM Kinase II and is used as a control for KN- 93.

Small volumes of Protein Kinase Inhibitor H-89 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6023990 is a biochemical targeting Protein Kinase Inhibitor H-89. Also known as Protein Kinase Inhibitor H-89 (PKI, N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide) (N-(2-p-bromocinnamylaminoethyl]-5-isoquinolinesulfonamide).