P21, WAF1 (CDKN1A) Antibody – Mouse Monoclonal

p21Cip1: a cell-cycle regulatory protein that Interacts with cyclin-CDK2 and -CDK4, inhibiting cell cycle progression at G1. Its expression is tightly controlled by p53, through which this protein mediates the p53-dependent cell cycle arrest at G1 phase.

Protein type: Inhibitor; Cell cycle regulation

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; perinuclear region of cytoplasm; cytoplasm; cyclin-dependent protein kinase holoenzyme complex; intracellular; cytosol; nucleus

Molecular Function: cyclin-dependent protein kinase inhibitor activity; cyclin binding; protein binding; cyclin-dependent protein kinase activating kinase activity; protein kinase inhibitor activity; metal ion binding; ubiquitin protein ligase binding; protein complex binding

Biological Process: regulation of cell cycle; regulation of mitotic cell cycle; negative regulation of cyclin-dependent protein kinase activity; cell cycle; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; protein amino acid phosphorylation; negative regulation of cell proliferation; positive regulation of programmed cell death; positive regulation of fibroblast proliferation; positive regulation of protein kinase activity; positive regulation of B cell proliferation; cellular response to extracellular stimulus; negative regulation of phosphorylation; regulation of protein import into nucleus, translocation; negative regulation of cell growth; regulation of cyclin-dependent protein kinase activity; G2/M transition of mitotic cell cycle; cell cycle arrest; response to DNA damage stimulus; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; response to UV; negative regulation of apoptosis; G1/S transition of mitotic cell cycle