Cdk6, P40 Antibody – Mouse Monoclonal

The cyclin-dependent kinases form complexes with their cyclin partners and with cdk inhibitors. cdk6 and cdk4 associate with the D-type cyclins and target the retinoblastoma protein, their major substrate—a necessary event for entry into S-phase in cells not deficient for pRb (1). Heterotrimeric complexes of cdk6/ cyclin D are sequestered in the inactive form by their inhibitory component p27 Kip1 or one of the INK4 proteins (2). Dissociation and degradation of the inhibitory CKIs from the trimeric complex allow exit from the restriction point and progression through G1 (3). Unlike the INK/Kip CKIs, p21 Waf1/Cip1 enhances association of cdk4 and cdk6 with their cyclin D partners (4).

Small volumes of anti-cdk6, p40 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS602544 is an antibody targeting cdk6, p40. Also known as cdk6, p40 (Cyclin-dependent Kinase 6, PLSTIRE). Reactive in Human, Mouse. Host: Mouse.