Kinesin, Light Chain (KLC1) Antibody – Mouse Monoclonal

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq]

KLC1: a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 14q32.3

Cellular Component: ciliary rootlet; kinesin complex; microtubule; growth cone; membrane; cell soma; axon; cytoplasmic membrane-bound vesicle; cytosol

Molecular Function: tubulin binding; protein binding; motor activity; microtubule motor activity

Biological Process: intracellular protein transport; viral reproduction; metabolic process; axon cargo transport; antigen processing and presentation of exogenous peptide antigen via MHC class II; blood coagulation; microtubule-based movement