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TPH1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602564

Tyrosine hydroxylase (TYH) is the enzyme which converts tyrosine to dihydroxyphenylalanine (L-dopa), a precursor of the catecholamine neurotransmitters dopamine, noradrenaline and adrenaline. Tryptophan hydroxylase (TRH) is the enzyme that converts… More details

$1085 / 0.5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TPH1), Monoclonal Antibody
Full Product Name
Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)
Product Gene Name
Product Synonym Names
Anti -Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
2Q122
Host
Mouse
Species Reactivity
Human, Rat
Form/Format
Supplied as a liquid in PBS, 40% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography. Sterile-filtered with a 0.22um filter.
Specificity
Binds a common epitope of human Tryptophan hydroxylase (TRH), Tyrosine hydroxylase (TYH) and Phenylalanine hydroxylase (PAH). Species Crossreactivity: Rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
18,331 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (18042084..18062335, complement). Location: 11p15.3-p14
3D Structure
ModBase 3D Structure for Q86Y20
Immunogen
Human phenylalanine hydroxylase sequence between aa139-155.

Product Categories/Family for anti-TPH1 antibody

Applications Tested/Suitable for anti-TPH1 antibody
Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
Application Notes for anti-TPH1 antibody
Suitable for use in the identification of dopaminergic and serotonergic neurons by Immunohistochemistry. Also suitable for Western Blot, Immunoprecipitation and Immunohistochemistry of TYH, PAH and TRH.
Dilution: Immunohistochemistry: 1:1000-1:5000

Other Notes

Small volumes of anti-TPH1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TPH1 purchase

MBS602564 is an antibody targeting TPH1. Also known as Tryptophan Hydroxylase, Tyrosine Hydroxylase & Phenylalanine Hydroxylase (TH, TYH, TRH, TYH, PAH, PH8, Tyrosine 3 Hydroxylase, Tyrosine 3 Monooxygenase). Reactive in Human, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TPH1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
tryptophan hydroxylase
NCBI Official Synonym Full Names
tryptophan hydroxylase 1
NCBI Official Symbol
TPH1
NCBI Official Synonym Symbols
TPRH; TRPH; MGC119994
UniProt Protein Name
Tryptophan hydroxylase
UniProt Entry Name
Q86Y20_HUMAN
NCBI Protein Information
tryptophan 5-hydroxylase 1; OTTHUMP00000232851; L-tryptophan hydroxylase; tryptophan 5-monooxygenase 1; indoleacetic acid-5-hydroxylase; tryptophan hydroxylase (tryptophan 5-monooxygenase)

NCBI Summary for TPH1

This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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