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Transcription Elongation Regulator 1 (TCERG1) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS602606

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing… More details

$610 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
Transcription Elongation Regulator 1 (TCERG1), Monoclonal Antibody
Full Product Name
Transcription Elongation Regulator 1 (TCERG1, CA150, MGC133200, TAF2S, TATA box-binding protein-associated factor 2S, Transcription factor CA150, Urn1)
Product Gene Name
anti-TCERG1 antibody
Product Synonym Names
Anti -Transcription Elongation Regulator 1 (TCERG1, CA150, MGC133200, TAF2S, TATA box-binding protein-associated factor 2S, Transcription factor CA150, Urn1)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
8C333
Host
Mouse
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in PBS, pH 7.4, 1% BSA, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human Transcription Elongation Regulator 1. Species Crossreactivity: mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
123,901 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (145826873..145891069). Location: 5q31
OMIM
605409
3D Structure
ModBase 3D Structure for O14776
Immunogen
Recombinant corresponding to a partial sequence of human Transcription Elongation Regulator 1.

Product Categories/Family for anti-TCERG1 antibody

Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-TCERG1 antibody
ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)
Application Notes for anti-TCERG1 antibody
Suitable for use in ELISA, Flow Cytometry, Immunocytochemistry, Immunofluorescence (IC) and Western Blot.
Dilution: Immunofluorescence (IC): 2-100ug/ml. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with
0.1% Triton X-100 in PBS.
Western Blot: 0.2-2ug/ml
Flow cytometry: 0.5-2ug/ml. HeLa cells with 2% paraformaldehyde/PBS and then permeabilized in 90% methanol.

Testing Data of anti-TCERG1 antibody

Detection of TCERG1 using MBS602606. Samples: Whole cell lysate from human A2058 (H, 50ug) , mouse NIH3T3 (M, 50ug) and rat F2408 (R, 50ug) cells. Predicted molecular weight: 123kD
Mouse Anti-TCERG1 Monoclonal Antibody – Cat# MBS602606

Testing Data of anti-TCERG1 antibody

HeLa cells were fixed in 2% paraformaldehyde/PBS and then permeabilized in 90% methanol. Cells were stained with O8056-05A (shaded) or isotype control (unshaded) followed by Alexa Fluor® 488- conjugated goat anti-mouse IgG.
Mouse Anti-TCERG1 Monoclonal Antibody, Testing Data – Cat# MBS602606

Immunostaining (IS) of anti-TCERG1 antibody

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.1% Triton X-100 in PBS. The cells were immunostained with MBS602606.
Mouse Anti-TCERG1 Monoclonal Antibody, Immunostaining (IS) – Cat# MBS602606

Other Notes

Small volumes of anti-TCERG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TCERG1 purchase

MBS602606 is an antibody targeting TCERG1. Also known as Transcription Elongation Regulator 1 (TCERG1, CA150, MGC133200, TAF2S, TATA box-binding protein-associated factor 2S, Transcription factor CA150, Urn1). Reactive in Human, Mouse, Rat. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for TCERG1. It may not necessarily be applicable to this product.

NCBI GI #
21327715
NCBI GeneID
10915
NCBI Accession #
NP_006697.2
UniProt Primary Accession #
O14776
UniProt Secondary Accession #
Q2NKN2; Q59EA1
UniProt Related Accession #
O14776
GenBank Nucleotide #
NM_006706.3
NCBI Official Full Name
transcription elongation regulator 1 isoform 1
NCBI Official Synonym Full Names
transcription elongation regulator 1
NCBI Official Symbol
TCERG1
NCBI Official Synonym Symbols
Urn1; CA150; TAF2S; MGC133200
UniProt Protein Name
Transcription elongation regulator 1
UniProt Synonym Protein Names
TATA box-binding protein-associated factor 2S; Transcription factor CA150
Protein Family
Transcription elongation regulator
UniProt Gene Name
TCERG1
UniProt Synonym Gene Names
CA150; TAF2S
UniProt Entry Name
TCRG1_HUMAN
NCBI Protein Information
transcription elongation regulator 1; OTTHUMP00000160091; OTTHUMP00000223941; co-activator of 150 kDa; transcription factor CA150; TATA box-binding protein-associated factor 2S; TATA box binding protein (TBP)-associated factor, RNA polymerase II, S, 150kD

NCBI Summary for TCERG1

This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms. [provided by RefSeq]
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UniProt Comments for TCERG1

TCERG1: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; RNA-binding; Spliceosome

Chromosomal Location of Human Ortholog: 5q31

Cellular Component: nucleolus; nucleus; actin cytoskeleton

Molecular Function: protein binding; transcription coactivator activity

Biological Process: transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter
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Research Articles on TCERG1

1. mutation of the SUMO acceptor lysine residues enhanced TCERG1 transcriptional activity, indicating that SUMO modification negatively regulates TCERG1 transcriptional activity

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TCERG1 antibody

 Reference Product  PubMed Publications
 SF1 antibody  >6 publications with TCERG1 and SF1
 HTT antibody  >3 publications with TCERG1 and HTT

Pathways associated with anti-TCERG1 antibody

 Products by Pathway  Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram
 Spliceosome Pathway antibodies  Spliceosome Pathway Diagram

Diseases associated with anti-TCERG1 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with TCERG1 and Carcinoma
 Adenocarcinoma Antibodies  >1 publications with TCERG1 and Adenocarcinoma
 Leukemia, Myeloid, Acute Antibodies  >1 publications with TCERG1 and Leukemia, Myeloid, Acute
 Carcinoma, Hepatocellular Antibodies  >1 publications with TCERG1 and Carcinoma, Hepatocellular
 Myelodysplastic Syndromes Antibodies  >1 publications with TCERG1 and Myelodysplastic Syndromes
 Liver Neoplasms Antibodies  >1 publications with TCERG1 and Liver Neoplasms
 Gonadal Disorders Antibodies  >1 publications with TCERG1 and Gonadal Disorders

Organs/Tissues associated with anti-TCERG1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with TCERG1 and Brain
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